FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077166988> ?p ?o ?g. }

• W2077166988 endingPage "32789" @default.
• W2077166988 startingPage "32775" @default.
• W2077166988 abstract "Histone deacetylases (HDACs) regulate fundamental biological processes such as cellular proliferation, differentiation, and survival via genomic and nongenomic effects. This study examined the importance of HDAC activity in the regulation of gene expression and differentiation of the developing mouse kidney. Class I HDAC1-3 and class II HDAC4, -7, and -9 genes are developmentally regulated. Moreover, HDAC1-3 are highly expressed in nephron precursors. Short term treatment of cultured mouse embryonic kidneys with HDAC inhibitors (HDACi) induced global histone H3 and H4 hyperacetylation and H3K4 hypermethylation. However, genome-wide profiling revealed that the HDAC-regulated transcriptome is restricted and encompasses regulators of the cell cycle, Wnt/β-catenin, TGF-β/Smad, and PI3K-AKT pathways. Further analysis demonstrated that base-line expression of key developmental renal regulators, including Osr1, Eya1, Pax2/8, WT1, Gdnf, Wnt9b, Sfrp1/2, and Emx2, is dependent on intact HDAC activity. Treatment of cultured embryonic kidney cells with HDACi recapitulated these gene expression changes, and chromatin immunoprecipitation assays revealed that HDACi is associated with histone hyperacetylation of Pax2/Pax8, Gdnf, Sfrp1, and p21. Gene knockdown studies demonstrated that HDAC1 and HDAC2 play a redundant role in regulation of Pax2/8 and Sfrp1 but not Gdnf. Long term treatment of embryonic kidneys with HDACi impairs the ureteric bud branching morphogenesis program and provokes growth arrest and apoptosis. We conclude that HDAC activity is critical for normal embryonic kidney homeostasis, and we implicate class I HDACs in the regulation of early nephron gene expression, differentiation, and survival." @default.
• W2077166988 created "2016-06-24" @default.
• W2077166988 creator A5001534228 @default.
• W2077166988 creator A5002654282 @default.
• W2077166988 creator A5016168447 @default.
• W2077166988 creator A5044765791 @default.
• W2077166988 creator A5049071636 @default.
• W2077166988 creator A5071884101 @default.
• W2077166988 creator A5073527850 @default.
• W2077166988 creator A5089950604 @default.
• W2077166988 date "2011-09-01" @default.
• W2077166988 modified "2023-10-12" @default.
• W2077166988 title "Histone Deacetylase (HDAC) Activity Is Critical for Embryonic Kidney Gene Expression, Growth, and Differentiation" @default.
• W2077166988 cites W1501475362 @default.
• W2077166988 cites W1592260247 @default.
• W2077166988 cites W1908134412 @default.
• W2077166988 cites W1910848366 @default.
• W2077166988 cites W1964575217 @default.
• W2077166988 cites W1965534679 @default.
• W2077166988 cites W1978664410 @default.
• W2077166988 cites W1978702203 @default.
• W2077166988 cites W1980020302 @default.
• W2077166988 cites W1982099181 @default.
• W2077166988 cites W1983228128 @default.
• W2077166988 cites W1983861034 @default.
• W2077166988 cites W1992611086 @default.
• W2077166988 cites W1997671473 @default.
• W2077166988 cites W2001671102 @default.
• W2077166988 cites W2012710154 @default.
• W2077166988 cites W2019727148 @default.
• W2077166988 cites W2027322371 @default.
• W2077166988 cites W2029283176 @default.
• W2077166988 cites W2032766842 @default.
• W2077166988 cites W2041425187 @default.
• W2077166988 cites W2043721269 @default.
• W2077166988 cites W2048814659 @default.
• W2077166988 cites W2049961455 @default.
• W2077166988 cites W2051998916 @default.
• W2077166988 cites W2054848045 @default.
• W2077166988 cites W2055233543 @default.
• W2077166988 cites W2056656235 @default.
• W2077166988 cites W2060836886 @default.
• W2077166988 cites W2064208027 @default.
• W2077166988 cites W2066079888 @default.
• W2077166988 cites W2066484100 @default.
• W2077166988 cites W2071263430 @default.
• W2077166988 cites W2071721087 @default.
• W2077166988 cites W2072106614 @default.
• W2077166988 cites W2076977331 @default.
• W2077166988 cites W2080112494 @default.
• W2077166988 cites W2083356835 @default.
• W2077166988 cites W2084585178 @default.
• W2077166988 cites W2084771218 @default.
• W2077166988 cites W2085073751 @default.
• W2077166988 cites W2088185221 @default.
• W2077166988 cites W2093734994 @default.
• W2077166988 cites W2098379349 @default.
• W2077166988 cites W2100847259 @default.
• W2077166988 cites W2102636621 @default.
• W2077166988 cites W2102884982 @default.
• W2077166988 cites W2106069796 @default.
• W2077166988 cites W2107733280 @default.
• W2077166988 cites W2108017291 @default.
• W2077166988 cites W2111623323 @default.
• W2077166988 cites W2113631993 @default.
• W2077166988 cites W2114626012 @default.
• W2077166988 cites W2116070901 @default.
• W2077166988 cites W2117287510 @default.
• W2077166988 cites W2123324115 @default.
• W2077166988 cites W2124877697 @default.
• W2077166988 cites W2125459722 @default.
• W2077166988 cites W2128179792 @default.
• W2077166988 cites W2129078547 @default.
• W2077166988 cites W2134371698 @default.
• W2077166988 cites W2135061086 @default.
• W2077166988 cites W2137504683 @default.
• W2077166988 cites W2138454311 @default.
• W2077166988 cites W2140523553 @default.
• W2077166988 cites W2141882676 @default.
• W2077166988 cites W2143416290 @default.
• W2077166988 cites W2143508168 @default.
• W2077166988 cites W2145111609 @default.
• W2077166988 cites W2149275036 @default.
• W2077166988 cites W2152509610 @default.
• W2077166988 cites W2154592003 @default.
• W2077166988 cites W2160005456 @default.
• W2077166988 cites W4244103891 @default.
• W2077166988 doi "https://doi.org/10.1074/jbc.m111.248278" @default.
• W2077166988 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3173185" @default.
• W2077166988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21778236" @default.
• W2077166988 hasPublicationYear "2011" @default.
• W2077166988 type Work @default.
• W2077166988 sameAs 2077166988 @default.
• W2077166988 citedByCount "82" @default.
• W2077166988 countsByYear W20771669882012 @default.
• W2077166988 countsByYear W20771669882013 @default.
• W2077166988 countsByYear W20771669882014 @default.
• W2077166988 countsByYear W20771669882015 @default.

• next