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- W2077168519 endingPage "101" @default.
- W2077168519 startingPage "90" @default.
- W2077168519 abstract "Cancer cells are characterized by an increase in the rate of reactive oxygen species (ROS) production and an altered redox environment compared to normal cells. Furthermore, redox regulation and redox signaling play a key role in tumorigenesis and in the response to cancer therapeutics. ROS have contradictory roles in tumorigenesis, which has important implications for the development of potential anticancer therapies that aim to modulate cellular redox levels. ROS play a causal role in tumor development and progression by inducing DNA mutations, genomic instability, and aberrant pro-tumorigenic signaling. On the other hand, high levels of ROS can also be toxic to cancer cells and can potentially induce cell death. To balance the state of oxidative stress, cancer cells increase their antioxidant capacity, which strongly suggests that high ROS levels have the potential to actually block tumorigenesis. This fact makes pro-oxidant cancer therapy an interesting area of study. In this review, we discuss the controversial role of ROS in tumorigenesis and especially elaborate on the advantages of targeting ROS scavengers, hence the antioxidant capacity of cancer cells, and how this can be utilized for cancer therapeutics." @default.
- W2077168519 created "2016-06-24" @default.
- W2077168519 creator A5003724875 @default.
- W2077168519 creator A5046518034 @default.
- W2077168519 date "2014-11-01" @default.
- W2077168519 modified "2023-10-16" @default.
- W2077168519 title "Targeting antioxidants for cancer therapy" @default.
- W2077168519 cites W1535828429 @default.
- W2077168519 cites W1547863599 @default.
- W2077168519 cites W1574058927 @default.
- W2077168519 cites W1678920698 @default.
- W2077168519 cites W1785455093 @default.
- W2077168519 cites W1821918060 @default.
- W2077168519 cites W1876742335 @default.
- W2077168519 cites W1940436875 @default.
- W2077168519 cites W1964691523 @default.
- W2077168519 cites W1964769336 @default.
- W2077168519 cites W1965148787 @default.
- W2077168519 cites W1966597938 @default.
- W2077168519 cites W1967108243 @default.
- W2077168519 cites W1967234838 @default.
- W2077168519 cites W1968044382 @default.
- W2077168519 cites W1968816740 @default.
- W2077168519 cites W1968967017 @default.
- W2077168519 cites W1969268163 @default.
- W2077168519 cites W1969524738 @default.
- W2077168519 cites W1970665658 @default.
- W2077168519 cites W1971967721 @default.
- W2077168519 cites W1972779889 @default.
- W2077168519 cites W1974690747 @default.
- W2077168519 cites W1975043122 @default.
- W2077168519 cites W1978795802 @default.
- W2077168519 cites W1979438083 @default.
- W2077168519 cites W1979657965 @default.
- W2077168519 cites W1980605560 @default.
- W2077168519 cites W1981868559 @default.
- W2077168519 cites W1982330633 @default.
- W2077168519 cites W1982395176 @default.
- W2077168519 cites W1983078193 @default.
- W2077168519 cites W1984799406 @default.
- W2077168519 cites W1987857240 @default.
- W2077168519 cites W1990983360 @default.
- W2077168519 cites W1991039871 @default.
- W2077168519 cites W1991214201 @default.
- W2077168519 cites W1992724001 @default.
- W2077168519 cites W1992918484 @default.
- W2077168519 cites W1993238109 @default.
- W2077168519 cites W1995443816 @default.
- W2077168519 cites W1998560601 @default.
- W2077168519 cites W2000718634 @default.
- W2077168519 cites W2002825673 @default.
- W2077168519 cites W2003173759 @default.
- W2077168519 cites W2006202974 @default.
- W2077168519 cites W2007793284 @default.
- W2077168519 cites W2008563361 @default.
- W2077168519 cites W2010023860 @default.
- W2077168519 cites W2010077871 @default.
- W2077168519 cites W2011006339 @default.
- W2077168519 cites W2013729686 @default.
- W2077168519 cites W2013911798 @default.
- W2077168519 cites W2014988241 @default.
- W2077168519 cites W2016313181 @default.
- W2077168519 cites W2016602233 @default.
- W2077168519 cites W2017275974 @default.
- W2077168519 cites W2017851212 @default.
- W2077168519 cites W2018276670 @default.
- W2077168519 cites W2018918759 @default.
- W2077168519 cites W2020177773 @default.
- W2077168519 cites W2020498032 @default.
- W2077168519 cites W2021469759 @default.
- W2077168519 cites W2023973783 @default.
- W2077168519 cites W2025034297 @default.
- W2077168519 cites W2025550779 @default.
- W2077168519 cites W2025571426 @default.
- W2077168519 cites W2027851837 @default.
- W2077168519 cites W2028187888 @default.
- W2077168519 cites W2028897202 @default.
- W2077168519 cites W2030410762 @default.
- W2077168519 cites W2033711861 @default.
- W2077168519 cites W2033910705 @default.
- W2077168519 cites W2034530633 @default.
- W2077168519 cites W2034580062 @default.
- W2077168519 cites W2034773856 @default.
- W2077168519 cites W2035712312 @default.
- W2077168519 cites W2037813091 @default.
- W2077168519 cites W2039620761 @default.
- W2077168519 cites W2040031153 @default.
- W2077168519 cites W2040856926 @default.
- W2077168519 cites W2041084592 @default.
- W2077168519 cites W2041149058 @default.
- W2077168519 cites W2041499308 @default.
- W2077168519 cites W2041992938 @default.
- W2077168519 cites W2043281296 @default.
- W2077168519 cites W2043549608 @default.
- W2077168519 cites W2048339025 @default.
- W2077168519 cites W2049637089 @default.
- W2077168519 cites W2052830369 @default.
- W2077168519 cites W2053047691 @default.