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• W2077169984 abstract "In mammalian cells, siRNAs have been used to induce RNA interference (RNAi) in an attempt to prevent nonspecific effects (including the interferon (IFN) response) which are caused by long double-stranded RNAs (dsRNAs) of more than 30 bp. In this report, we describe a novel and simple strategy for avoiding activation of the IFN response by dsRNA. We show that modified hairpin-RNAs (mhRNAs) of more than 100 bp, with multiple specific point-mutations within the sense strand and transcribed from the U6 or tRNAVal promoters, can cause RNAi without inducing the IFN pathway genes. Moreover, we demonstrate that the 50-bp mhRNA vector could effectively suppress the replication of multiple hepatitis C viruses (the genomes of which differ slightly, thus the 21-bp siRNA vector failed to suppress one of them). Our findings should enhance the exploitation of RNAi in mammalian cells, especially in the field of RNAi therapy against pathogenic viruses." @default.
• W2077169984 created "2016-06-24" @default.
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• W2077169984 date "2005-01-01" @default.
• W2077169984 modified "2023-10-10" @default.
• W2077169984 title "Escape from the interferon response associated with RNA interference using vectors that encode long modified hairpin-RNA" @default.
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• W2077169984 doi "https://doi.org/10.1039/b510159j" @default.
• W2077169984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16881007" @default.
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