FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077173694> ?p ?o ?g. }

• W2077173694 endingPage "1111" @default.
• W2077173694 startingPage "1103" @default.
• W2077173694 abstract "Chemokines are chemoattractant cytokines defined by the presence of four conserved cysteine residues. In mammals, these cytokines can be divided into four subfamilies depending on the arrangement of the first two conserved cysteines in the sequence, and include the CXC(α), CC(β), C(γ), and CX3C(δ) classes. We identified CXC chemokine cDNA, designated RbCXC, isolated using expressed sequence tag analysis of a lipopolysaccharide (LPS)-stimulated rock bream liver cDNA library. The full-length RbCXC cDNA (742 bp) contained an open reading frame of 342 bp encoding 114 amino acids. Results from phylogenetic analysis showed that RbCXC was strictly separated into a distinct clade compared to other known CXC chemokine subgroups. RbCXC was significantly expressed in the trunk kidney, liver, spleen, gill, peripheral blood leukocytes (PBLs), and head kidney. Rock bream PBLs were stimulated with several mitogens, including LPS and polyinosinic-polycytidylic acid (poly I:C), which significantly induced the expression of RbCXC mRNA. RbCXC mRNA expression was examined in several tissues under conditions of bacterial and viral challenge. Experimental challenges revealed that all examined tissues from fish infected with Edwardsiella tarda and red sea bream iridovirus showed significant increases in RbCXC expression compared to the control. In the case of Streptococcus iniae infection, RbCXC mRNA expression was markedly upregulated in the kidney, spleen, and liver. In addition, a maltose binding protein fusion recombinant RbCXC (~53 kDa) was produced in an Escherichia coli expression system and purified. Subsequently, the addition of purified recombinant RbCXC (rRbCXC) to kidney leukocytes was examined to investigate the impact of proliferative and chemotactic activity. The rRbCXC induced significant kidney leukocyte proliferation and attraction at concentrations ranging from 10 to 300 μg/mL, suggesting that it can be utilised as an immune stimulant and/or molecular adjuvant to enhance the immunological effects of vaccines." @default.
• W2077173694 created "2016-06-24" @default.
• W2077173694 creator A5032523073 @default.
• W2077173694 creator A5046688257 @default.
• W2077173694 creator A5053104393 @default.
• W2077173694 creator A5066920530 @default.
• W2077173694 creator A5076778973 @default.
• W2077173694 date "2013-05-01" @default.
• W2077173694 modified "2023-10-16" @default.
• W2077173694 title "Molecular characterisation and biological activity of a novel CXC chemokine gene in rock bream (Oplegnathus fasciatus)" @default.
• W2077173694 cites W1607819524 @default.
• W2077173694 cites W1963786981 @default.
• W2077173694 cites W1967519218 @default.
• W2077173694 cites W1970318694 @default.
• W2077173694 cites W1973139773 @default.
• W2077173694 cites W1973237909 @default.
• W2077173694 cites W1973810022 @default.
• W2077173694 cites W1974301074 @default.
• W2077173694 cites W1975773489 @default.
• W2077173694 cites W1978882591 @default.
• W2077173694 cites W1992474320 @default.
• W2077173694 cites W1996539617 @default.
• W2077173694 cites W2009869230 @default.
• W2077173694 cites W2013784675 @default.
• W2077173694 cites W2014587187 @default.
• W2077173694 cites W2019948813 @default.
• W2077173694 cites W2022592406 @default.
• W2077173694 cites W2040129479 @default.
• W2077173694 cites W2040228198 @default.
• W2077173694 cites W2042383304 @default.
• W2077173694 cites W2044961357 @default.
• W2077173694 cites W2051542016 @default.
• W2077173694 cites W2060447390 @default.
• W2077173694 cites W2061060193 @default.
• W2077173694 cites W2063160102 @default.
• W2077173694 cites W2066497770 @default.
• W2077173694 cites W2067535806 @default.
• W2077173694 cites W2069895301 @default.
• W2077173694 cites W2071902341 @default.
• W2077173694 cites W2073540188 @default.
• W2077173694 cites W2075785603 @default.
• W2077173694 cites W2084380234 @default.
• W2077173694 cites W2091599169 @default.
• W2077173694 cites W2102540234 @default.
• W2077173694 cites W2102956203 @default.
• W2077173694 cites W2103969000 @default.
• W2077173694 cites W2104918497 @default.
• W2077173694 cites W2107277218 @default.
• W2077173694 cites W2114123652 @default.
• W2077173694 cites W2125121305 @default.
• W2077173694 cites W2130892977 @default.
• W2077173694 cites W2151453636 @default.
• W2077173694 cites W2156645558 @default.
• W2077173694 cites W2157464163 @default.
• W2077173694 cites W2159520551 @default.
• W2077173694 cites W2172294747 @default.
• W2077173694 cites W2172874896 @default.
• W2077173694 cites W2330590881 @default.
• W2077173694 cites W4234072569 @default.
• W2077173694 cites W4296792904 @default.
• W2077173694 cites W97158386 @default.
• W2077173694 doi "https://doi.org/10.1016/j.fsi.2013.01.007" @default.
• W2077173694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23376472" @default.
• W2077173694 hasPublicationYear "2013" @default.
• W2077173694 type Work @default.
• W2077173694 sameAs 2077173694 @default.
• W2077173694 citedByCount "17" @default.
• W2077173694 countsByYear W20771736942014 @default.
• W2077173694 countsByYear W20771736942015 @default.
• W2077173694 countsByYear W20771736942016 @default.
• W2077173694 countsByYear W20771736942017 @default.
• W2077173694 countsByYear W20771736942019 @default.
• W2077173694 countsByYear W20771736942020 @default.
• W2077173694 countsByYear W20771736942022 @default.
• W2077173694 countsByYear W20771736942023 @default.
• W2077173694 crossrefType "journal-article" @default.
• W2077173694 hasAuthorship W2077173694A5032523073 @default.
• W2077173694 hasAuthorship W2077173694A5046688257 @default.
• W2077173694 hasAuthorship W2077173694A5053104393 @default.
• W2077173694 hasAuthorship W2077173694A5066920530 @default.
• W2077173694 hasAuthorship W2077173694A5076778973 @default.
• W2077173694 hasConcept C104317684 @default.
• W2077173694 hasConcept C13373296 @default.
• W2077173694 hasConcept C153911025 @default.
• W2077173694 hasConcept C167625842 @default.
• W2077173694 hasConcept C187882448 @default.
• W2077173694 hasConcept C189482833 @default.
• W2077173694 hasConcept C203014093 @default.
• W2077173694 hasConcept C2776832872 @default.
• W2077173694 hasConcept C45240729 @default.
• W2077173694 hasConcept C47289529 @default.
• W2077173694 hasConcept C55493867 @default.
• W2077173694 hasConcept C5858377 @default.
• W2077173694 hasConcept C86803240 @default.
• W2077173694 hasConcept C8891405 @default.
• W2077173694 hasConcept C89423630 @default.
• W2077173694 hasConceptScore W2077173694C104317684 @default.
• W2077173694 hasConceptScore W2077173694C13373296 @default.

• next