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- W2077173882 abstract "Strong experimental evidence has been presented to support the proposition that inhibitors can be constructed which fit the active site of an enzyme reversibly, then become irreversibly bound by alkylation of the enzyme adjacent to the active site (exo-alkylation). 4-(Iodoacetamido)-salicylic acid most probably inactivates glutamic and lactic dehydrogenases by this mechanism. The fact that glutamic dehydrogenase is not inactivated by iodoacetamide is an important contrast." @default.
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- W2077173882 date "1962-11-01" @default.
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- W2077173882 title "Non-classical antimetabolites. VI. 4-(Iodoacetamido)-salicylic acid, an exo-alkylating irreversible inhibitor" @default.
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- W2077173882 doi "https://doi.org/10.1016/s0022-5193(62)80037-x" @default.
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