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- W2077175364 abstract "Administration of orotate, an intermediate in pyrimidine nucleotide biosynthesis, has been shown to elevate the levels of acid soluble uracil [l-6] and cytosine nucleotides [S] in liver. Furthermore, activities of enzymes involved in the de novo synthesis of pyrimidine nucleotides increase following the administration of orotate; this has been demonstrated for aspartate carbamoyl transferase (EC 2.1.3.2) and dihydro-orotase (EC 3.5.2.3) in rat liver [7]. In yeast, a sequential induction of enzymes of pyrimidine biosynthesis by an intermediate of this pathway (dihydroorotate) was observed [8]. Elevated uracil nucleotide contents as well as an increased rate of uridylate biosynthesis in liver have been considered essential for the prevention of galactosamine-induced hepatitis by orotate [9, lo] . Data will now be presented indicating that orotate administration leads to increased activities of the hepatic enzymes catalyzing the conversion of orotate to UMP." @default.
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- W2077175364 date "1972-02-15" @default.
- W2077175364 modified "2023-09-27" @default.
- W2077175364 title "Increased activities of hepatic orotidine 5′-phosphate pyrophosphorylase and orotidine 5′-phosphate decarboxylase induced by orotate" @default.
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- W2077175364 doi "https://doi.org/10.1016/0014-5793(72)80099-1" @default.
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