Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077181854> ?p ?o ?g. }
- W2077181854 endingPage "2116" @default.
- W2077181854 startingPage "2102" @default.
- W2077181854 abstract "Quality control systems facilitate polypeptide folding and degradation to maintain protein homeostasis. Molecular chaperones promote folding, whereas the ubiquitin/proteasome system mediates degradation. We show here that Saccharomyces cerevisiae Ubr1 and Ubr2 ubiquitin ligases promote degradation of unfolded or misfolded cytosolic polypeptides. Ubr1 also catalyzes ubiquitinylation of denatured but not native luciferase in a purified system. This activity is based on the direct interaction of denatured luciferase with Ubr1, although Hsp70 stimulates polyubiquitinylation of the denatured substrate. We also report that loss of Ubr1 and Ubr2 function suppressed the growth arrest phenotype resulting from chaperone mutation. This correlates with increased protein kinase maturation and indicates partitioning of foldable conformers toward the proteasome. Our findings, based on the efficiency of this quality control system, suggest that the cell trades growth potential to avert the potential toxicity associated with accumulation of unfolded or misfolded proteins. Ubr1 and Ubr2 therefore represent E3 components of a novel quality control pathway for proteins synthesized on cytosolic ribosomes." @default.
- W2077181854 created "2016-06-24" @default.
- W2077181854 creator A5006104220 @default.
- W2077181854 creator A5012287134 @default.
- W2077181854 creator A5026672801 @default.
- W2077181854 creator A5028283040 @default.
- W2077181854 creator A5030361320 @default.
- W2077181854 creator A5035058978 @default.
- W2077181854 creator A5044416813 @default.
- W2077181854 creator A5051020425 @default.
- W2077181854 creator A5054369961 @default.
- W2077181854 creator A5089946620 @default.
- W2077181854 date "2010-07-01" @default.
- W2077181854 modified "2023-09-27" @default.
- W2077181854 title "Ubr1 and Ubr2 Function in a Quality Control Pathway for Degradation of Unfolded Cytosolic Proteins" @default.
- W2077181854 cites W1483766000 @default.
- W2077181854 cites W1520171546 @default.
- W2077181854 cites W1541948779 @default.
- W2077181854 cites W1605149529 @default.
- W2077181854 cites W1782287000 @default.
- W2077181854 cites W1789882194 @default.
- W2077181854 cites W1838616807 @default.
- W2077181854 cites W1967025628 @default.
- W2077181854 cites W1967358425 @default.
- W2077181854 cites W1971302334 @default.
- W2077181854 cites W1982888373 @default.
- W2077181854 cites W1985598278 @default.
- W2077181854 cites W1986342078 @default.
- W2077181854 cites W2000755989 @default.
- W2077181854 cites W2004362709 @default.
- W2077181854 cites W2008559063 @default.
- W2077181854 cites W2014675809 @default.
- W2077181854 cites W2021040301 @default.
- W2077181854 cites W2022531767 @default.
- W2077181854 cites W2025356047 @default.
- W2077181854 cites W2034764834 @default.
- W2077181854 cites W2045350410 @default.
- W2077181854 cites W2048815297 @default.
- W2077181854 cites W2058326770 @default.
- W2077181854 cites W2058775823 @default.
- W2077181854 cites W2063513058 @default.
- W2077181854 cites W2066168326 @default.
- W2077181854 cites W2066844134 @default.
- W2077181854 cites W2067708969 @default.
- W2077181854 cites W2074273512 @default.
- W2077181854 cites W2076159058 @default.
- W2077181854 cites W2079139546 @default.
- W2077181854 cites W2081104776 @default.
- W2077181854 cites W2081841423 @default.
- W2077181854 cites W2090681601 @default.
- W2077181854 cites W2092548312 @default.
- W2077181854 cites W2093950531 @default.
- W2077181854 cites W2094572545 @default.
- W2077181854 cites W2097350262 @default.
- W2077181854 cites W2102184626 @default.
- W2077181854 cites W2107442883 @default.
- W2077181854 cites W2108412187 @default.
- W2077181854 cites W2110125737 @default.
- W2077181854 cites W2110913873 @default.
- W2077181854 cites W2113836064 @default.
- W2077181854 cites W2116504799 @default.
- W2077181854 cites W2118843271 @default.
- W2077181854 cites W2130171645 @default.
- W2077181854 cites W2135845161 @default.
- W2077181854 cites W2139188448 @default.
- W2077181854 cites W2140702339 @default.
- W2077181854 cites W2151697744 @default.
- W2077181854 cites W2153850735 @default.
- W2077181854 cites W2158848184 @default.
- W2077181854 cites W4214850937 @default.
- W2077181854 doi "https://doi.org/10.1091/mbc.e10-02-0098" @default.
- W2077181854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2893976" @default.
- W2077181854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20462952" @default.
- W2077181854 hasPublicationYear "2010" @default.
- W2077181854 type Work @default.
- W2077181854 sameAs 2077181854 @default.
- W2077181854 citedByCount "121" @default.
- W2077181854 countsByYear W20771818542012 @default.
- W2077181854 countsByYear W20771818542013 @default.
- W2077181854 countsByYear W20771818542014 @default.
- W2077181854 countsByYear W20771818542015 @default.
- W2077181854 countsByYear W20771818542016 @default.
- W2077181854 countsByYear W20771818542017 @default.
- W2077181854 countsByYear W20771818542018 @default.
- W2077181854 countsByYear W20771818542019 @default.
- W2077181854 countsByYear W20771818542020 @default.
- W2077181854 countsByYear W20771818542021 @default.
- W2077181854 countsByYear W20771818542022 @default.
- W2077181854 countsByYear W20771818542023 @default.
- W2077181854 crossrefType "journal-article" @default.
- W2077181854 hasAuthorship W2077181854A5006104220 @default.
- W2077181854 hasAuthorship W2077181854A5012287134 @default.
- W2077181854 hasAuthorship W2077181854A5026672801 @default.
- W2077181854 hasAuthorship W2077181854A5028283040 @default.
- W2077181854 hasAuthorship W2077181854A5030361320 @default.
- W2077181854 hasAuthorship W2077181854A5035058978 @default.
- W2077181854 hasAuthorship W2077181854A5044416813 @default.
- W2077181854 hasAuthorship W2077181854A5051020425 @default.