FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077183901> ?p ?o ?g. }

• W2077183901 endingPage "21" @default.
• W2077183901 startingPage "12" @default.
• W2077183901 abstract "Liriodenine (L), an antitumor active ingredient from the traditional Chinese medicine (TCM), Zanthoxylum nitidum, afforded a platinum(II) complex (1) of L, cis-[PtCl2(L)(DMSO)], which previously reported for its in vitro antitumor activity and intercalative binding with DNA. In this study, complex 1 was further discussed for its antitumor mechanism and structure–activity relationship, comparing with L and cisplatin. Towards the most sensitive BEL-7404 human hepatoma cells, complex 1 significantly induced cell cycle arrest at both G2/M phase and S phase. It suggests that double helix DNA is not the simplex intracellular target for 1. On the other hand, the BEL-7404 cells incubated with 1 and stained by Hoechst 33258 and AO/EB showed typical cell apoptosis in dose-dependent manner. The BEL-7404 cells incubated with 1 and stained by JC-1 were also characteristic for cell apoptosis on the loss of mitochondrial membrane potential. Furthermore, the G-quadruplex DNA binding property of complex 1 was also investigated by spectroscopic analyses, fluorescent indicator displacement (FID) assay and fluorescence resonance energy transfer (FRET) assay. The results indicated that 1 stabilized the human telomeric G4-HTG21 DNA better than L. The telomerase inhibition ratio of 1 ((62.50 ± 0.03)%), which was examined by telomerase polymerase chain reaction-enzyme-linked immunosorbent assay (PCR-ELISA), was much higher than L ((21.77 ± 0.01)%). It can be ascribed to the better G4-HTG21 DNA stabilization of 1 than L. The results suggested that the nuclei, mitochondria and telomerase via G-quadruplex DNA stabilization all should be key targets for the antitumor mechanism of 1, in which the central platinum(II) played a key role." @default.
• W2077183901 created "2016-06-24" @default.
• W2077183901 creator A5016171867 @default.
• W2077183901 creator A5018545990 @default.
• W2077183901 creator A5045123174 @default.
• W2077183901 creator A5059996188 @default.
• W2077183901 creator A5068149448 @default.
• W2077183901 date "2014-08-01" @default.
• W2077183901 modified "2023-09-28" @default.
• W2077183901 title "A platinum(II) complex of liriodenine from traditional Chinese medicine (TCM): Cell cycle arrest, cell apoptosis induction and telomerase inhibition activity via G-quadruplex DNA stabilization" @default.
• W2077183901 cites W107210068 @default.
• W2077183901 cites W1927051535 @default.
• W2077183901 cites W1963899001 @default.
• W2077183901 cites W1965195352 @default.
• W2077183901 cites W1970801073 @default.
• W2077183901 cites W1976272817 @default.
• W2077183901 cites W1979395573 @default.
• W2077183901 cites W1981358003 @default.
• W2077183901 cites W1985991521 @default.
• W2077183901 cites W1987848600 @default.
• W2077183901 cites W1997213816 @default.
• W2077183901 cites W2000971601 @default.
• W2077183901 cites W2006578412 @default.
• W2077183901 cites W2006706167 @default.
• W2077183901 cites W2008120871 @default.
• W2077183901 cites W2008794525 @default.
• W2077183901 cites W2012176494 @default.
• W2077183901 cites W2014089590 @default.
• W2077183901 cites W2038969376 @default.
• W2077183901 cites W2043219843 @default.
• W2077183901 cites W2045569766 @default.
• W2077183901 cites W2051376250 @default.
• W2077183901 cites W2052445290 @default.
• W2077183901 cites W2073707228 @default.
• W2077183901 cites W2074342766 @default.
• W2077183901 cites W2083078381 @default.
• W2077183901 cites W2089362593 @default.
• W2077183901 cites W2092324565 @default.
• W2077183901 cites W2092452241 @default.
• W2077183901 cites W2114289148 @default.
• W2077183901 cites W2121704353 @default.
• W2077183901 cites W2123535919 @default.
• W2077183901 cites W2127213026 @default.
• W2077183901 cites W2137986693 @default.
• W2077183901 cites W2145745052 @default.
• W2077183901 cites W2153164448 @default.
• W2077183901 cites W2153207180 @default.
• W2077183901 cites W2154564031 @default.
• W2077183901 cites W2156049851 @default.
• W2077183901 cites W2160001764 @default.
• W2077183901 cites W2160185049 @default.
• W2077183901 cites W2165810890 @default.
• W2077183901 cites W2166723844 @default.
• W2077183901 cites W2329555214 @default.
• W2077183901 doi "https://doi.org/10.1016/j.jinorgbio.2014.04.001" @default.
• W2077183901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24798373" @default.
• W2077183901 hasPublicationYear "2014" @default.
• W2077183901 type Work @default.
• W2077183901 sameAs 2077183901 @default.
• W2077183901 citedByCount "23" @default.
• W2077183901 countsByYear W20771839012015 @default.
• W2077183901 countsByYear W20771839012016 @default.
• W2077183901 countsByYear W20771839012017 @default.
• W2077183901 countsByYear W20771839012018 @default.
• W2077183901 countsByYear W20771839012019 @default.
• W2077183901 countsByYear W20771839012020 @default.
• W2077183901 countsByYear W20771839012021 @default.
• W2077183901 countsByYear W20771839012022 @default.
• W2077183901 countsByYear W20771839012023 @default.
• W2077183901 crossrefType "journal-article" @default.
• W2077183901 hasAuthorship W2077183901A5016171867 @default.
• W2077183901 hasAuthorship W2077183901A5018545990 @default.
• W2077183901 hasAuthorship W2077183901A5045123174 @default.
• W2077183901 hasAuthorship W2077183901A5059996188 @default.
• W2077183901 hasAuthorship W2077183901A5068149448 @default.
• W2077183901 hasConcept C104317684 @default.
• W2077183901 hasConcept C105696609 @default.
• W2077183901 hasConcept C121332964 @default.
• W2077183901 hasConcept C153911025 @default.
• W2077183901 hasConcept C185592680 @default.
• W2077183901 hasConcept C190283241 @default.
• W2077183901 hasConcept C2776694085 @default.
• W2077183901 hasConcept C2778239845 @default.
• W2077183901 hasConcept C29537977 @default.
• W2077183901 hasConcept C54355233 @default.
• W2077183901 hasConcept C552990157 @default.
• W2077183901 hasConcept C55493867 @default.
• W2077183901 hasConcept C62520636 @default.
• W2077183901 hasConcept C79879829 @default.
• W2077183901 hasConcept C86803240 @default.
• W2077183901 hasConcept C91881484 @default.
• W2077183901 hasConcept C94581717 @default.
• W2077183901 hasConcept C96305047 @default.
• W2077183901 hasConceptScore W2077183901C104317684 @default.
• W2077183901 hasConceptScore W2077183901C105696609 @default.
• W2077183901 hasConceptScore W2077183901C121332964 @default.
• W2077183901 hasConceptScore W2077183901C153911025 @default.
• W2077183901 hasConceptScore W2077183901C185592680 @default.

• next