FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077184059> ?p ?o ?g. }

• W2077184059 endingPage "817" @default.
• W2077184059 startingPage "812" @default.
• W2077184059 abstract "New Zealand obese (NZO) mice exhibit a polygenic syndrome of obesity, insulin resistance, and hypercholesterolemia that resembles the human metabolic syndrome. This study was performed in order to locate genes responsible for elevated serum cholesterol and to compare their effects under a standard and high fat diet.A backcross population of NZO with SJL mice (NZO x F1(SJL x NZO)) was generated. Mice were raised on a normal or high fat diet and were monitored for 22 weeks (body weight, serum cholesterol, and blood glucose). A genome-wide scan was performed by genotyping of approximately 200 polymorphic microsatellite markers by PCR and linkage analysis was performed with the MAPMAKER program.In the genome-wide scan, a single susceptibility locus for hypercholesterolemia (Chol1/NZO, maximum LOD score 14.5 in a combined population of 523 backcross mice) was identified on chromosome 5. Cholesterol levels were significantly elevated in both male and female homozygous carriers of the Chol1/NZO allele. The locus maps 40cM distal of the previously described obesity locus Nob1 in the vicinity of the marker D5Mit244 and in the vicinity of hypercholesterolemia QTL previously identified in the NZB, CAST, and C57BL/6J strains. Chol1/NZO was not associated with elevated body weight, serum insulin, or hyperglycemia. The high fat diet significantly increased serum cholesterol levels, but the fat content of the diet did not alter the absolute effect of Chol1/NZO.Chol1/NZO is a major susceptibility locus on the distal mouse chromosome 5, which produces gender-independent hypercholesterolemia in NZO mice. The effect of Chol1/NZO was independent of the dietary fat content and was not associated with the other traits of the metabolic syndrome. Thus, it is suggested that the responsible gene might be involved in cholesterol metabolism." @default.
• W2077184059 created "2016-06-24" @default.
• W2077184059 creator A5015600499 @default.
• W2077184059 creator A5029736084 @default.
• W2077184059 creator A5050114501 @default.
• W2077184059 creator A5070289680 @default.
• W2077184059 creator A5072012847 @default.
• W2077184059 date "2003-05-01" @default.
• W2077184059 modified "2023-09-26" @default.
• W2077184059 title "Diet-dependent obesity and hypercholesterolemia in the New Zealand obese mouse: identification of a quantitative trait locus for elevated serum cholesterol on the distal mouse chromosome 5" @default.
• W2077184059 cites W1780351937 @default.
• W2077184059 cites W1905082515 @default.
• W2077184059 cites W2008938453 @default.
• W2077184059 cites W2010607788 @default.
• W2077184059 cites W2014977165 @default.
• W2077184059 cites W2030046033 @default.
• W2077184059 cites W2032777955 @default.
• W2077184059 cites W2052333527 @default.
• W2077184059 cites W2064681938 @default.
• W2077184059 cites W2076180913 @default.
• W2077184059 cites W2076989008 @default.
• W2077184059 cites W2080831128 @default.
• W2077184059 cites W2107971069 @default.
• W2077184059 cites W2128016314 @default.
• W2077184059 cites W2134903073 @default.
• W2077184059 cites W2138104224 @default.
• W2077184059 cites W2144774847 @default.
• W2077184059 cites W2163137121 @default.
• W2077184059 cites W2166399744 @default.
• W2077184059 cites W2187695897 @default.
• W2077184059 cites W2916596946 @default.
• W2077184059 doi "https://doi.org/10.1016/s0006-291x(03)00664-8" @default.
• W2077184059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12727230" @default.
• W2077184059 hasPublicationYear "2003" @default.
• W2077184059 type Work @default.
• W2077184059 sameAs 2077184059 @default.
• W2077184059 citedByCount "34" @default.
• W2077184059 countsByYear W20771840592012 @default.
• W2077184059 countsByYear W20771840592013 @default.
• W2077184059 countsByYear W20771840592014 @default.
• W2077184059 countsByYear W20771840592015 @default.
• W2077184059 countsByYear W20771840592017 @default.
• W2077184059 countsByYear W20771840592022 @default.
• W2077184059 crossrefType "journal-article" @default.
• W2077184059 hasAuthorship W2077184059A5015600499 @default.
• W2077184059 hasAuthorship W2077184059A5029736084 @default.
• W2077184059 hasAuthorship W2077184059A5050114501 @default.
• W2077184059 hasAuthorship W2077184059A5070289680 @default.
• W2077184059 hasAuthorship W2077184059A5072012847 @default.
• W2077184059 hasConcept C104317684 @default.
• W2077184059 hasConcept C126322002 @default.
• W2077184059 hasConcept C134018914 @default.
• W2077184059 hasConcept C180754005 @default.
• W2077184059 hasConcept C2777391703 @default.
• W2077184059 hasConcept C2778163477 @default.
• W2077184059 hasConcept C2780578515 @default.
• W2077184059 hasConcept C2908647359 @default.
• W2077184059 hasConcept C511355011 @default.
• W2077184059 hasConcept C54355233 @default.
• W2077184059 hasConcept C71924100 @default.
• W2077184059 hasConcept C81941488 @default.
• W2077184059 hasConcept C84597430 @default.
• W2077184059 hasConcept C86803240 @default.
• W2077184059 hasConcept C99454951 @default.
• W2077184059 hasConceptScore W2077184059C104317684 @default.
• W2077184059 hasConceptScore W2077184059C126322002 @default.
• W2077184059 hasConceptScore W2077184059C134018914 @default.
• W2077184059 hasConceptScore W2077184059C180754005 @default.
• W2077184059 hasConceptScore W2077184059C2777391703 @default.
• W2077184059 hasConceptScore W2077184059C2778163477 @default.
• W2077184059 hasConceptScore W2077184059C2780578515 @default.
• W2077184059 hasConceptScore W2077184059C2908647359 @default.
• W2077184059 hasConceptScore W2077184059C511355011 @default.
• W2077184059 hasConceptScore W2077184059C54355233 @default.
• W2077184059 hasConceptScore W2077184059C71924100 @default.
• W2077184059 hasConceptScore W2077184059C81941488 @default.
• W2077184059 hasConceptScore W2077184059C84597430 @default.
• W2077184059 hasConceptScore W2077184059C86803240 @default.
• W2077184059 hasConceptScore W2077184059C99454951 @default.
• W2077184059 hasIssue "4" @default.
• W2077184059 hasLocation W20771840591 @default.
• W2077184059 hasLocation W20771840592 @default.
• W2077184059 hasOpenAccess W2077184059 @default.
• W2077184059 hasPrimaryLocation W20771840591 @default.
• W2077184059 hasRelatedWork W1979252938 @default.
• W2077184059 hasRelatedWork W2032225465 @default.
• W2077184059 hasRelatedWork W2057739827 @default.
• W2077184059 hasRelatedWork W2110282787 @default.
• W2077184059 hasRelatedWork W2169206971 @default.
• W2077184059 hasRelatedWork W2378290744 @default.
• W2077184059 hasRelatedWork W2584731720 @default.
• W2077184059 hasRelatedWork W2886303208 @default.
• W2077184059 hasRelatedWork W2910989958 @default.
• W2077184059 hasRelatedWork W2969331335 @default.
• W2077184059 hasVolume "304" @default.
• W2077184059 isParatext "false" @default.
• W2077184059 isRetracted "false" @default.
• W2077184059 magId "2077184059" @default.

• next