Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077184517> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2077184517 endingPage "S119" @default.
- W2077184517 startingPage "S115" @default.
- W2077184517 abstract "Benzodiazepines, mainly diazepam, are commonly used as anticonvulsants in the treatment of organophosphate casualties. Although very effective, diazepam usually is not used in prophylactic treatments because of its adverse effects on task performance and its abuse liability. Benzodiazepine (BZ) partial agonists are unique in that they are able to occupy all the population of a given receptor without eliciting the maximal physiological response. The BZ receptor agonistic occupancy was found to differ among the various physiological responses in the following order: antipanic > anticonvulsion > sedation > muscle relaxation. Thus, partial agonists, by the use of which controlled levels of agonistic activity can be achieved, might serve as effective anticonvulsants, with fewer side-effects. Bretazenil, a partial agonist, was found to counteract metrazol-induced convulsions in rats. At the anticonvulsive doses (125-250 microg x kg(-1), i.p.) bretazenil, in combination with pyridostigmine (100 microg x kg(-1), i.m.) and aprophen (4 mg x kg(-1), i.m.), conferred prophylactic protection against sarin and soman poisoning (protective ratios 2.6 and 2.1, respectively). Relevant doses of bretazenil (50-400 microg x kg(-1), i.p.) also were tested for general behavioural effects in the open field and for its anti-anxiety properties in the plus maze. The incapacitation was much lower compared with diazepam. Bretazenil should be considered as a candidate for incorporating into a prophylactic mixture as a central nervous system protectant, with significant advantages concerning incapacitation." @default.
- W2077184517 created "2016-06-24" @default.
- W2077184517 creator A5009129179 @default.
- W2077184517 creator A5023282385 @default.
- W2077184517 creator A5027406634 @default.
- W2077184517 creator A5046109966 @default.
- W2077184517 creator A5049465406 @default.
- W2077184517 creator A5052501641 @default.
- W2077184517 creator A5068378119 @default.
- W2077184517 creator A5070866785 @default.
- W2077184517 creator A5082790426 @default.
- W2077184517 date "2001-12-01" @default.
- W2077184517 modified "2023-09-26" @default.
- W2077184517 title "Bretazenil, a benzodiazepine receptor partial agonist, as an adjunct in the prophylactic treatment of OP poisoning" @default.
- W2077184517 cites W1995504883 @default.
- W2077184517 cites W2008322352 @default.
- W2077184517 cites W2067039447 @default.
- W2077184517 cites W2074977195 @default.
- W2077184517 cites W2079257658 @default.
- W2077184517 cites W2084906880 @default.
- W2077184517 cites W2085993644 @default.
- W2077184517 cites W2095774921 @default.
- W2077184517 cites W2100488616 @default.
- W2077184517 cites W2111775018 @default.
- W2077184517 doi "https://doi.org/10.1002/jat.810" @default.
- W2077184517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11920931" @default.
- W2077184517 hasPublicationYear "2001" @default.
- W2077184517 type Work @default.
- W2077184517 sameAs 2077184517 @default.
- W2077184517 citedByCount "14" @default.
- W2077184517 countsByYear W20771845172013 @default.
- W2077184517 countsByYear W20771845172014 @default.
- W2077184517 countsByYear W20771845172017 @default.
- W2077184517 countsByYear W20771845172018 @default.
- W2077184517 countsByYear W20771845172019 @default.
- W2077184517 countsByYear W20771845172022 @default.
- W2077184517 crossrefType "journal-article" @default.
- W2077184517 hasAuthorship W2077184517A5009129179 @default.
- W2077184517 hasAuthorship W2077184517A5023282385 @default.
- W2077184517 hasAuthorship W2077184517A5027406634 @default.
- W2077184517 hasAuthorship W2077184517A5046109966 @default.
- W2077184517 hasAuthorship W2077184517A5049465406 @default.
- W2077184517 hasAuthorship W2077184517A5052501641 @default.
- W2077184517 hasAuthorship W2077184517A5068378119 @default.
- W2077184517 hasAuthorship W2077184517A5070866785 @default.
- W2077184517 hasAuthorship W2077184517A5082790426 @default.
- W2077184517 hasConcept C126322002 @default.
- W2077184517 hasConcept C170493617 @default.
- W2077184517 hasConcept C185592680 @default.
- W2077184517 hasConcept C2776175493 @default.
- W2077184517 hasConcept C2777123777 @default.
- W2077184517 hasConcept C2778173252 @default.
- W2077184517 hasConcept C2778938600 @default.
- W2077184517 hasConcept C2781210498 @default.
- W2077184517 hasConcept C2908647359 @default.
- W2077184517 hasConcept C42219234 @default.
- W2077184517 hasConcept C58732023 @default.
- W2077184517 hasConcept C71924100 @default.
- W2077184517 hasConcept C98274493 @default.
- W2077184517 hasConcept C99454951 @default.
- W2077184517 hasConceptScore W2077184517C126322002 @default.
- W2077184517 hasConceptScore W2077184517C170493617 @default.
- W2077184517 hasConceptScore W2077184517C185592680 @default.
- W2077184517 hasConceptScore W2077184517C2776175493 @default.
- W2077184517 hasConceptScore W2077184517C2777123777 @default.
- W2077184517 hasConceptScore W2077184517C2778173252 @default.
- W2077184517 hasConceptScore W2077184517C2778938600 @default.
- W2077184517 hasConceptScore W2077184517C2781210498 @default.
- W2077184517 hasConceptScore W2077184517C2908647359 @default.
- W2077184517 hasConceptScore W2077184517C42219234 @default.
- W2077184517 hasConceptScore W2077184517C58732023 @default.
- W2077184517 hasConceptScore W2077184517C71924100 @default.
- W2077184517 hasConceptScore W2077184517C98274493 @default.
- W2077184517 hasConceptScore W2077184517C99454951 @default.
- W2077184517 hasIssue "S1" @default.
- W2077184517 hasLocation W20771845171 @default.
- W2077184517 hasLocation W20771845172 @default.
- W2077184517 hasOpenAccess W2077184517 @default.
- W2077184517 hasPrimaryLocation W20771845171 @default.
- W2077184517 hasRelatedWork W2005248040 @default.
- W2077184517 hasRelatedWork W2015592783 @default.
- W2077184517 hasRelatedWork W2039453452 @default.
- W2077184517 hasRelatedWork W2043205042 @default.
- W2077184517 hasRelatedWork W2061945417 @default.
- W2077184517 hasRelatedWork W2066548714 @default.
- W2077184517 hasRelatedWork W2084767251 @default.
- W2077184517 hasRelatedWork W2087011017 @default.
- W2077184517 hasRelatedWork W2090470362 @default.
- W2077184517 hasRelatedWork W45593278 @default.
- W2077184517 hasVolume "21" @default.
- W2077184517 isParatext "false" @default.
- W2077184517 isRetracted "false" @default.
- W2077184517 magId "2077184517" @default.
- W2077184517 workType "article" @default.