FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077184810> ?p ?o ?g. }

• W2077184810 endingPage "298" @default.
• W2077184810 startingPage "285" @default.
• W2077184810 abstract "Recent studies have found an association between presence of apolipoprotein E (APOE) η4 allele and Alzheimer's disease (AD). The present study compared the cumulative risk of primary progressive dementia (PPD) in relatives of AD probands carrying at least one copy of the η4 allele with the relatives of AD probands not carrying η4 and with relatives of non-demented controls. Our aim was to determine whether the familial aggregation of PPD in relatives of AD probands is primarily due to those carrying η4. Seventy-seven neuropathologically diagnosed AD patients were obtained as probands through our Alzheimer's Disease Research Center Brain Bank. AD probands were genotyped for APOE. As a comparison group, 198 non-demented probands were also included. Through family informants, demographic and diagnostic data were collected on 382 first-degree relatives (age ≥ 45 years) of AD probands and 848 relatives of the controls. We found that the cumulative risk of PPD in both relatives of AD probands with and without the η4 allele was significantly higher than that in the relatives of non-demented controls. However, the increased risk in the relatives of AD probands with the η4 allele was marginally, but not significantly, lower than the risk in the relatives of probands without η4. A greater likelihood of death by heart diseases over developing PPD in relatives of AD probands with η4 (3.1-fold increase) was found compared to relatives of probands without η4 (1.7-fold increase), especially prior to age 70, although the difference was not statistically significant. The increased familial risk for PPD in the relatives of AD probands with the APOE-η4 allele relative to controls suggests that familial factors in addition to APOE-η4 are risk factors for AD. Differential censorship from increased mortality of heart diseases may have prevented a higher incidence of PPD among the relatives of probands with η4. © 1996 Wiley-Liss, Inc." @default.
• W2077184810 created "2016-06-24" @default.
• W2077184810 creator A5000219240 @default.
• W2077184810 creator A5037912275 @default.
• W2077184810 creator A5054795331 @default.
• W2077184810 creator A5072771360 @default.
• W2077184810 creator A5073252588 @default.
• W2077184810 creator A5074185152 @default.
• W2077184810 creator A5080155420 @default.
• W2077184810 creator A5081083643 @default.
• W2077184810 creator A5084874491 @default.
• W2077184810 creator A5087473363 @default.
• W2077184810 date "1996-01-01" @default.
• W2077184810 modified "2023-10-18" @default.
• W2077184810 title "Apolipoprotein E-η4 allele and familial risk in Alzheimer's disease" @default.
• W2077184810 cites W1919970019 @default.
• W2077184810 cites W1965607488 @default.
• W2077184810 cites W1971718473 @default.
• W2077184810 cites W1982120496 @default.
• W2077184810 cites W1983271161 @default.
• W2077184810 cites W1989175221 @default.
• W2077184810 cites W1998290897 @default.
• W2077184810 cites W1999631936 @default.
• W2077184810 cites W2011199056 @default.
• W2077184810 cites W2016537454 @default.
• W2077184810 cites W2019697190 @default.
• W2077184810 cites W2021181758 @default.
• W2077184810 cites W2025215809 @default.
• W2077184810 cites W2025739392 @default.
• W2077184810 cites W2026761055 @default.
• W2077184810 cites W2033356439 @default.
• W2077184810 cites W2036362108 @default.
• W2077184810 cites W2053152816 @default.
• W2077184810 cites W2058116753 @default.
• W2077184810 cites W2058723245 @default.
• W2077184810 cites W2066644955 @default.
• W2077184810 cites W2067842196 @default.
• W2077184810 cites W2081569845 @default.
• W2077184810 cites W2083633251 @default.
• W2077184810 cites W2090271811 @default.
• W2077184810 cites W2091716473 @default.
• W2077184810 cites W2102715685 @default.
• W2077184810 cites W2108386133 @default.
• W2077184810 cites W2111774300 @default.
• W2077184810 cites W2113456980 @default.
• W2077184810 cites W2115363308 @default.
• W2077184810 cites W2146729934 @default.
• W2077184810 cites W2154171427 @default.
• W2077184810 cites W2156337263 @default.
• W2077184810 cites W2312625132 @default.
• W2077184810 cites W2413378659 @default.
• W2077184810 cites W4233622592 @default.
• W2077184810 doi "https://doi.org/10.1002/(sici)1098-2272(1996)13:3<285::aid-gepi5>3.0.co;2-5" @default.
• W2077184810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8797010" @default.
• W2077184810 hasPublicationYear "1996" @default.
• W2077184810 type Work @default.
• W2077184810 sameAs 2077184810 @default.
• W2077184810 citedByCount "19" @default.
• W2077184810 countsByYear W20771848102016 @default.
• W2077184810 crossrefType "journal-article" @default.
• W2077184810 hasAuthorship W2077184810A5000219240 @default.
• W2077184810 hasAuthorship W2077184810A5037912275 @default.
• W2077184810 hasAuthorship W2077184810A5054795331 @default.
• W2077184810 hasAuthorship W2077184810A5072771360 @default.
• W2077184810 hasAuthorship W2077184810A5073252588 @default.
• W2077184810 hasAuthorship W2077184810A5074185152 @default.
• W2077184810 hasAuthorship W2077184810A5080155420 @default.
• W2077184810 hasAuthorship W2077184810A5081083643 @default.
• W2077184810 hasAuthorship W2077184810A5084874491 @default.
• W2077184810 hasAuthorship W2077184810A5087473363 @default.
• W2077184810 hasConcept C104317684 @default.
• W2077184810 hasConcept C126322002 @default.
• W2077184810 hasConcept C180754005 @default.
• W2077184810 hasConcept C188997412 @default.
• W2077184810 hasConcept C203083617 @default.
• W2077184810 hasConcept C2779134260 @default.
• W2077184810 hasConcept C2779483572 @default.
• W2077184810 hasConcept C501734568 @default.
• W2077184810 hasConcept C502032728 @default.
• W2077184810 hasConcept C50440223 @default.
• W2077184810 hasConcept C54355233 @default.
• W2077184810 hasConcept C57089818 @default.
• W2077184810 hasConcept C71924100 @default.
• W2077184810 hasConcept C86803240 @default.
• W2077184810 hasConceptScore W2077184810C104317684 @default.
• W2077184810 hasConceptScore W2077184810C126322002 @default.
• W2077184810 hasConceptScore W2077184810C180754005 @default.
• W2077184810 hasConceptScore W2077184810C188997412 @default.
• W2077184810 hasConceptScore W2077184810C203083617 @default.
• W2077184810 hasConceptScore W2077184810C2779134260 @default.
• W2077184810 hasConceptScore W2077184810C2779483572 @default.
• W2077184810 hasConceptScore W2077184810C501734568 @default.
• W2077184810 hasConceptScore W2077184810C502032728 @default.
• W2077184810 hasConceptScore W2077184810C50440223 @default.
• W2077184810 hasConceptScore W2077184810C54355233 @default.
• W2077184810 hasConceptScore W2077184810C57089818 @default.
• W2077184810 hasConceptScore W2077184810C71924100 @default.
• W2077184810 hasConceptScore W2077184810C86803240 @default.

• next