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• W2077186957 abstract "C-terminal amidation is often a requisite structural feature for peptide hormone bio-activity. We report a chemical amidation method that converts peptide/protein thioesters into their corresponding C-terminal amides. The peptide/protein thioester is treated with 1-(2,4-dimethoxyphenyl)-2-mercaptoethyl auxiliary (1b) in a native chemical ligation (NCL) reaction to form an intermediate, which upon removal of the auxiliary with TFA, yields the peptide/protein amide. We have demonstrated the general utility of the approach by successfully converting several synthetic peptide thioesters to peptide amides with high conversion rates. Preliminary results of converting a recombinant peptide thioester to its amide form are also reported." @default.
• W2077186957 created "2016-06-24" @default.
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• W2077186957 date "2013-09-01" @default.
• W2077186957 modified "2023-10-18" @default.
• W2077186957 title "Native chemical ligation derived method for recombinant peptide/protein C-terminal amidation" @default.
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• W2077186957 doi "https://doi.org/10.1016/j.bmcl.2013.06.095" @default.
• W2077186957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23880540" @default.
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