FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077187072> ?p ?o ?g. }

• W2077187072 endingPage "204" @default.
• W2077187072 startingPage "195" @default.
• W2077187072 abstract "Cell surface receptors for the vitamins folic acid and biotin have been previously reported to mediate the endocytosis of vitamin-conjugated macromolecules into cultured cells. To evaluate whether a similar uptake pathway for riboflavin-conjugated macromolecules might exist, riboflavin was covalently linked to bovine serum albumin (BSA) via the vitamin’s ribityl side chain, and uptake of the protein by cultured human cells was examined. Whereas unconjugated BSA was not internalized by KB, A549, SK-LU-1 or SK-OV cells, riboflavin-conjugated BSA was readily internalized (>106 molecules/cell). Analysis of the uptake pathway revealed that the riboflavin-BSA conjugate likely docks on cells at a carrier/transport protein that is distinct from the uptake pathway for free riboflavin and then enters via normal membrane cycling. Evidence for this contention is: (i) the internalized conjugate accumulates in endosomal compartments, (ii) uptake into cells is halted at temperatures near 0°C where membrane trafficking is abrogated, (iii) cell association is inhibited by unlabeled riboflavin-BSA, but not by free riboflavin, and (iv) cellular uptake of [3H]riboflavin is only partially inhibited by riboflavin-BSA. Regardless of the pathway of internalization, these data demonstrate that riboflavin conjugation can facilitate protein entry into human cells in culture." @default.
• W2077187072 created "2016-06-24" @default.
• W2077187072 creator A5020374620 @default.
• W2077187072 creator A5035852598 @default.
• W2077187072 creator A5038613600 @default.
• W2077187072 creator A5040022220 @default.
• W2077187072 creator A5064616169 @default.
• W2077187072 creator A5076878753 @default.
• W2077187072 creator A5085542989 @default.
• W2077187072 creator A5089609044 @default.
• W2077187072 date "1999-01-04" @default.
• W2077187072 modified "2023-10-11" @default.
• W2077187072 title "Riboflavin-mediated delivery of a macromolecule into cultured human cells" @default.
• W2077187072 cites W1502914656 @default.
• W2077187072 cites W1541948403 @default.
• W2077187072 cites W1546439690 @default.
• W2077187072 cites W1556341726 @default.
• W2077187072 cites W1576238436 @default.
• W2077187072 cites W1592761587 @default.
• W2077187072 cites W161944040 @default.
• W2077187072 cites W1853165005 @default.
• W2077187072 cites W1970812755 @default.
• W2077187072 cites W1972016531 @default.
• W2077187072 cites W1979206164 @default.
• W2077187072 cites W1980939469 @default.
• W2077187072 cites W2013331789 @default.
• W2077187072 cites W2039003309 @default.
• W2077187072 cites W2041643052 @default.
• W2077187072 cites W2042874420 @default.
• W2077187072 cites W2059554391 @default.
• W2077187072 cites W2081189233 @default.
• W2077187072 cites W2084357980 @default.
• W2077187072 cites W2150055875 @default.
• W2077187072 cites W2161547245 @default.
• W2077187072 cites W2164188238 @default.
• W2077187072 cites W2244238582 @default.
• W2077187072 doi "https://doi.org/10.1016/s0304-4165(98)00147-0" @default.
• W2077187072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9878734" @default.
• W2077187072 hasPublicationYear "1999" @default.
• W2077187072 type Work @default.
• W2077187072 sameAs 2077187072 @default.
• W2077187072 citedByCount "32" @default.
• W2077187072 countsByYear W20771870722012 @default.
• W2077187072 countsByYear W20771870722014 @default.
• W2077187072 countsByYear W20771870722015 @default.
• W2077187072 countsByYear W20771870722016 @default.
• W2077187072 countsByYear W20771870722017 @default.
• W2077187072 countsByYear W20771870722020 @default.
• W2077187072 crossrefType "journal-article" @default.
• W2077187072 hasAuthorship W2077187072A5020374620 @default.
• W2077187072 hasAuthorship W2077187072A5035852598 @default.
• W2077187072 hasAuthorship W2077187072A5038613600 @default.
• W2077187072 hasAuthorship W2077187072A5040022220 @default.
• W2077187072 hasAuthorship W2077187072A5064616169 @default.
• W2077187072 hasAuthorship W2077187072A5076878753 @default.
• W2077187072 hasAuthorship W2077187072A5085542989 @default.
• W2077187072 hasAuthorship W2077187072A5089609044 @default.
• W2077187072 hasConcept C102747710 @default.
• W2077187072 hasConcept C121608353 @default.
• W2077187072 hasConcept C134306372 @default.
• W2077187072 hasConcept C139770010 @default.
• W2077187072 hasConcept C1491633281 @default.
• W2077187072 hasConcept C185592680 @default.
• W2077187072 hasConcept C197336794 @default.
• W2077187072 hasConcept C2776155809 @default.
• W2077187072 hasConcept C2778106830 @default.
• W2077187072 hasConcept C2778204606 @default.
• W2077187072 hasConcept C2780306303 @default.
• W2077187072 hasConcept C28005876 @default.
• W2077187072 hasConcept C33923547 @default.
• W2077187072 hasConcept C54355233 @default.
• W2077187072 hasConcept C55493867 @default.
• W2077187072 hasConcept C86803240 @default.
• W2077187072 hasConcept C86807702 @default.
• W2077187072 hasConcept C95444343 @default.
• W2077187072 hasConcept C96232424 @default.
• W2077187072 hasConceptScore W2077187072C102747710 @default.
• W2077187072 hasConceptScore W2077187072C121608353 @default.
• W2077187072 hasConceptScore W2077187072C134306372 @default.
• W2077187072 hasConceptScore W2077187072C139770010 @default.
• W2077187072 hasConceptScore W2077187072C1491633281 @default.
• W2077187072 hasConceptScore W2077187072C185592680 @default.
• W2077187072 hasConceptScore W2077187072C197336794 @default.
• W2077187072 hasConceptScore W2077187072C2776155809 @default.
• W2077187072 hasConceptScore W2077187072C2778106830 @default.
• W2077187072 hasConceptScore W2077187072C2778204606 @default.
• W2077187072 hasConceptScore W2077187072C2780306303 @default.
• W2077187072 hasConceptScore W2077187072C28005876 @default.
• W2077187072 hasConceptScore W2077187072C33923547 @default.
• W2077187072 hasConceptScore W2077187072C54355233 @default.
• W2077187072 hasConceptScore W2077187072C55493867 @default.
• W2077187072 hasConceptScore W2077187072C86803240 @default.
• W2077187072 hasConceptScore W2077187072C86807702 @default.
• W2077187072 hasConceptScore W2077187072C95444343 @default.
• W2077187072 hasConceptScore W2077187072C96232424 @default.
• W2077187072 hasIssue "1" @default.
• W2077187072 hasLocation W20771870721 @default.
• W2077187072 hasLocation W20771870722 @default.

• next