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- W2077202018 endingPage "140" @default.
- W2077202018 startingPage "130" @default.
- W2077202018 abstract "•Acidic phospholipids are minor lipid species but have major functions. •Acidic phospholipids ionically interact with polybasic proteins. •Ionic protein–lipid interactions regulate protein structure and function. •Ca2+ can regulate ionic protein–lipid interactions via direct and indirect mechanisms. Phospholipids are the major components of cell membranes, but they have functional roles beyond forming lipid bilayers. In particular, acidic phospholipids form microdomains in the plasma membrane and can ionically interact with proteins via polybasic sequences, which can have functional consequences for the protein. The list of proteins regulated by ionic protein–lipid interaction has been quickly expanding, and now includes membrane proteins, cytoplasmic soluble proteins, and viral proteins. Here we review how acidic phospholipids in the plasma membrane regulate protein structure and function via ionic interactions, and how Ca2+ regulates ionic protein–lipid interactions via direct and indirect mechanisms. Phospholipids are the major components of cell membranes, but they have functional roles beyond forming lipid bilayers. In particular, acidic phospholipids form microdomains in the plasma membrane and can ionically interact with proteins via polybasic sequences, which can have functional consequences for the protein. The list of proteins regulated by ionic protein–lipid interaction has been quickly expanding, and now includes membrane proteins, cytoplasmic soluble proteins, and viral proteins. Here we review how acidic phospholipids in the plasma membrane regulate protein structure and function via ionic interactions, and how Ca2+ regulates ionic protein–lipid interactions via direct and indirect mechanisms." @default.
- W2077202018 created "2016-06-24" @default.
- W2077202018 creator A5019439005 @default.
- W2077202018 creator A5019802538 @default.
- W2077202018 creator A5040568735 @default.
- W2077202018 creator A5048105460 @default.
- W2077202018 creator A5079874838 @default.
- W2077202018 date "2014-03-01" @default.
- W2077202018 modified "2023-10-15" @default.
- W2077202018 title "Ionic protein–lipid interaction at the plasma membrane: what can the charge do?" @default.
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