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- W2077202464 abstract "Recent reports supporting linkage of bipolar affective disorder to X-chromosome markers raise certain questions, which must be settled before linkage can be accepted. These are: (1) Association vs linkage The available data, on color blindness and affective illness shows an association of the two traits across pedigrees, such that persons who are color-blind tend to be affectively ill. This association would not exist on the basis of chromosomal linkage alone, which would produce an association of the two traits within individual pedigrees but not across pedigrees. (2) Analytic methods In a psychiatric disorder with multiple manifestations and a variable age of onset, the use of analytic methods that require that each informative person be definitely ill or well does not allow for errors in classification of persons who have not passed through the age of risk. Unipolar illness in families of bipolar patients has been assumed to be a manifestation of bipolar disorder; the possibility of phenocopies or of independent unipolar illness appearing in these pedigrees and producing falsely positive findings of illness has not been taken into account. (3) Ambiguous pedigrees Some of the reported families are subject to alternate analyses and may not be informative for linkage. (4) Chromosomal map distance incompatibility The reported close linkage of bipolar illness to both the Xg blood group and the protan and deutan forms of color blindness is not compatible with the known large chromosomal map distance between the Xg locus and the protan-deutan region of the X-chromosome." @default.
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- W2077202464 title "The question of X-linkage in bipolar manic-depressive illness" @default.
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- W2077202464 doi "https://doi.org/10.1016/0022-3956(77)90012-7" @default.
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