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- W2077203424 abstract "Colchicine inhibition of messenger RNA release from rat liver nuclei has been analyzed in a cell-free system, which supports the processing and transport of functional RNA. The degree of inhibition is porportional to the colchicine concentration above 300 μM. The site of action is not microtubular elements associated with the nuclei, since some colchicine analogs containing a trimethoxy-benzene ring do not disrupt microtubules, but still inhibit RNA transport. Furthermore, the Vinca alkaloids, which like colchicine disrupt microtubules, do not inhibit messenger RNA transport. From an assessment of its effect on nuclear RNA metabolism, it is concluded that colchicine inhibits RNA release by inhibiting RNA transport rather than RNA processing. This effect may be due to the specific binding of colchicine to the nuclear membrane." @default.
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- W2077203424 date "1982-03-01" @default.
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- W2077203424 title "Site of action of colchicine on RNA release from liver nuclei" @default.
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- W2077203424 doi "https://doi.org/10.1016/s0006-291x(82)80055-7" @default.
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