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• W2077203886 abstract "Optimization of a water soluble, moderately potent lead series of isoxazole-3-carboxamides was conducted, affording a compound with the requisite balance of potency, solubility and physicochemical properties for in vivo use. Compound 8e was demonstrated to be efficacious in a rat model of inflammatory pain, following oral administration." @default.
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• W2077203886 date "2011-04-01" @default.
• W2077203886 modified "2023-09-28" @default.
• W2077203886 title "Identification of potent, soluble, and orally active TRPV1 antagonists" @default.
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• W2077203886 doi "https://doi.org/10.1016/j.bmcl.2011.01.112" @default.
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