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- W2077204559 abstract "The incretin hormones glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have recently received much attention for their roles in type 2 diabetes therapy. GLP-1 stimulated insulin secretion in a glucose-dependent manner and is secreted by intestinal L cells. It also regulates blood glucose concentration, stomach motility, appetite, and body weight. These actions are mediated through G-proteincoupled receptors highly expressed on pancreatic beta cells and also exert indirect metabolic actions. Activation of GLP-1 receptors also produces nonglycemic effects in various tissues. The pleiotropic effects of GLP-1 have been recently reported. The mechanisms identified in preclinical studies have potential translational relevance for the treatment of disease. Here, the nonglycemic effects of GLP-1, especially those on the liver, central nervous system, and bone, were reviewed. (J Korean Diabetes 2013;14:120-124)" @default.
- W2077204559 created "2016-06-24" @default.
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- W2077204559 date "2013-01-01" @default.
- W2077204559 modified "2023-10-16" @default.
- W2077204559 title "Pleiotropic Effects of an Incretin Hormone" @default.
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- W2077204559 doi "https://doi.org/10.4093/jkd.2013.14.3.120" @default.
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