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• W2077210462 abstract "The functional residual capacity (FRC) and airway resistance (Raw) of the rat were measured, using a newly designed body plethysmograph (BPG), the inner environment of which was maintained at body temperature and was water-vapor saturated. The subjects were anesthetized and tracheally intubated male Wistar rats (n = 15). After measuring the FRC and Raw, we analyzed the effects of inhaled methacholine (Mch, 0–8 mg/ml) on Raw.The determined FRC was 5.37 ± 0.22 ml (mean ± SE). An almost linear relationship between box pressure and respiratory flow was obtained when the difference between box-gas temperature and the rectal temperature of the rat was less than 1.0°C. The Raw at FRC was 0.230 ± 0.017 cmH2O/ml/s. It increased proportionally with increases in the Mch concentration. When the dynamic changes in Raw were analyzed, the Raw was found to progressively increase during expiration; this increase continued throughout inspiration. Thus in the rat, Raw is not simply a function of changes in lung volume. In conclusion, the humidity- and temperature-adjusted BPG provided an absolute and possibly dynamic value of Raw." @default.
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• W2077210462 date "2006-01-01" @default.
• W2077210462 modified "2023-10-17" @default.
• W2077210462 title "Functional Residual Capacity and Airway Resistance of the Rat Measured with a Heat- and Temperature-Adjusted Body Plethysmograph" @default.
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• W2077210462 doi "https://doi.org/10.2170/physiolsci.rp004506" @default.
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