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- W2077217595 abstract "Abstract Data from the literature demonstrate the existence of a growing family of neuropoietic cytokines; members of this group have structural motifs in common with other members and with neurotrophic factors. In this research we studied the responses elicited in vitro by some of these molecules in two different neuronal populations: murine neuroblastoma N18TG2 and neurons from chicken dorsal root ganglia. Both IL‐2 and IL‐6 improve the survival of murine neuroblastoma cells in clonal density plating experiments; in addition IL‐2 significantly inhibits thymidine incorporation by single cell suspension. The survival of sensory neurons, on the other hand, non‐responsive to IL‐2 and IL‐6, was significantly supported by IL‐3, which also stimulates their morphological differentiation, inducing the formation of a well‐developed neural net. In conclusion, results reported here confirm the neurotrophic activity of some ILs and provide additional neuronal models for future investigations." @default.
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- W2077217595 date "1995-02-01" @default.
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- W2077217595 title "Enhanced survival and differentiation<i>in vitro</i>of different neuronal populations by some interleukins" @default.
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- W2077217595 doi "https://doi.org/10.1016/0736-5748(94)00059-c" @default.
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