Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077220416> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2077220416 endingPage "769" @default.
- W2077220416 startingPage "761" @default.
- W2077220416 abstract "Treatment with tamoxifen increased the risk of endometrial cancers in breast cancer patients and women participating in the chemoprevention study. In our laboratory, tamoxifen−DNA adducts, including α-(N2-deoxyguanosinyl)tamoxifen (dG-N2-TAM), were detected in the endometrium of women taking tamoxifen [Shibutani, S., et al. (1999) Chem. Res. Toxicol. 12, 646−653]. On the basis of recent animal studies, deoxyguanosinyl-N-desmethyltamoxifen (dG-N-desmethylTAM) adducts are also suspected to be formed in the liver. In the study presented here, we synthesized α-acetoxy-N-desmethyltamoxifen as a model activated metabolite of N-desmethyltamoxifen. The overall yield of α-acetoxy-N-desmethyltamoxifen from α-hydroxytamoxifen was approximately 42%. α-Acetoxy-N-desmethyltamoxifen was highly reactive to 2‘-deoxyguanosine, as was similarly observed for tamoxifen α-sulfate. The two reaction products were identified as a mixture of epimers of the trans form or cis form of α-(N2-deoxyguanosinyl)-N-desmethyltamoxifen (dG-N2-N-desmethylTAM) by mass and proton magnetic resonance spectroscopy. In addition, the trans and cis forms of dG 3‘-monophosphate-N2-N-desmethylTAM were prepared as standard markers for 32P-postlabeling/HPLC analysis. Using this technique, dG-N2-N-desmethylTAM adducts were detected in calf thymus DNA reacted with α-acetoxy-N-desmethyltamoxifen." @default.
- W2077220416 created "2016-06-24" @default.
- W2077220416 creator A5015846611 @default.
- W2077220416 creator A5022933638 @default.
- W2077220416 creator A5029052236 @default.
- W2077220416 creator A5032632228 @default.
- W2077220416 creator A5043626990 @default.
- W2077220416 creator A5063749811 @default.
- W2077220416 creator A5073872707 @default.
- W2077220416 date "2000-07-19" @default.
- W2077220416 modified "2023-09-26" @default.
- W2077220416 title "Identification of Tamoxifen−DNA Adducts Induced by α-Acetoxy-<i>N</i>-desmethyltamoxifen" @default.
- W2077220416 cites W2064869480 @default.
- W2077220416 doi "https://doi.org/10.1021/tx000074o" @default.
- W2077220416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10956064" @default.
- W2077220416 hasPublicationYear "2000" @default.
- W2077220416 type Work @default.
- W2077220416 sameAs 2077220416 @default.
- W2077220416 citedByCount "14" @default.
- W2077220416 countsByYear W20772204162012 @default.
- W2077220416 crossrefType "journal-article" @default.
- W2077220416 hasAuthorship W2077220416A5015846611 @default.
- W2077220416 hasAuthorship W2077220416A5022933638 @default.
- W2077220416 hasAuthorship W2077220416A5029052236 @default.
- W2077220416 hasAuthorship W2077220416A5032632228 @default.
- W2077220416 hasAuthorship W2077220416A5043626990 @default.
- W2077220416 hasAuthorship W2077220416A5063749811 @default.
- W2077220416 hasAuthorship W2077220416A5073872707 @default.
- W2077220416 hasConcept C108204754 @default.
- W2077220416 hasConcept C121608353 @default.
- W2077220416 hasConcept C126322002 @default.
- W2077220416 hasConcept C153911025 @default.
- W2077220416 hasConcept C178790620 @default.
- W2077220416 hasConcept C185592680 @default.
- W2077220416 hasConcept C2777176818 @default.
- W2077220416 hasConcept C2777477808 @default.
- W2077220416 hasConcept C530470458 @default.
- W2077220416 hasConcept C55493867 @default.
- W2077220416 hasConcept C71924100 @default.
- W2077220416 hasConcept C86803240 @default.
- W2077220416 hasConceptScore W2077220416C108204754 @default.
- W2077220416 hasConceptScore W2077220416C121608353 @default.
- W2077220416 hasConceptScore W2077220416C126322002 @default.
- W2077220416 hasConceptScore W2077220416C153911025 @default.
- W2077220416 hasConceptScore W2077220416C178790620 @default.
- W2077220416 hasConceptScore W2077220416C185592680 @default.
- W2077220416 hasConceptScore W2077220416C2777176818 @default.
- W2077220416 hasConceptScore W2077220416C2777477808 @default.
- W2077220416 hasConceptScore W2077220416C530470458 @default.
- W2077220416 hasConceptScore W2077220416C55493867 @default.
- W2077220416 hasConceptScore W2077220416C71924100 @default.
- W2077220416 hasConceptScore W2077220416C86803240 @default.
- W2077220416 hasIssue "8" @default.
- W2077220416 hasLocation W20772204161 @default.
- W2077220416 hasLocation W20772204162 @default.
- W2077220416 hasOpenAccess W2077220416 @default.
- W2077220416 hasPrimaryLocation W20772204161 @default.
- W2077220416 hasRelatedWork W1965243176 @default.
- W2077220416 hasRelatedWork W2016472295 @default.
- W2077220416 hasRelatedWork W2024050959 @default.
- W2077220416 hasRelatedWork W2035115059 @default.
- W2077220416 hasRelatedWork W2047991101 @default.
- W2077220416 hasRelatedWork W2107114875 @default.
- W2077220416 hasRelatedWork W2334792521 @default.
- W2077220416 hasRelatedWork W2341880960 @default.
- W2077220416 hasRelatedWork W2951566524 @default.
- W2077220416 hasRelatedWork W3138975019 @default.
- W2077220416 hasVolume "13" @default.
- W2077220416 isParatext "false" @default.
- W2077220416 isRetracted "false" @default.
- W2077220416 magId "2077220416" @default.
- W2077220416 workType "article" @default.