Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077224993> ?p ?o ?g. }
- W2077224993 endingPage "20" @default.
- W2077224993 startingPage "13" @default.
- W2077224993 abstract "Naringin, a bioflavonoid, has been reported to have potent neuro-protective effects, but its preventive effects on amyloid-β (Aβ) induced, Alzheimer's disease (AD) related, cognitive impairment, and the underlying mechanisms of these effects have not been well characterised. Three-month-old APPswe/PSΔE9 transgenic mice were randomly assigned to a vehicle group, two naringin (either 50 or 100 mg/kg/day) groups, or an Aricept (2 mg/kg/day) group. After 16 weeks of treatment, we observed beneficial effects of naringin (100 mg/kg/day), including lessening learning and memory deficits, improving locomotor activity, reducing scattered senile plaques, and ameliorating disturbances in brain energy metabolism. Furthermore, GSK-3β phosphorylation significantly increased in the naringin-treated (100 mg/kg/day) group. These findings suggest that a reduction in plaque burden and an increase in glucose uptake through the inhibition of GSK-3β activity may be one of the mechanisms by which naringin improves cognitive functioning in the APPswe/ PSΔE9 transgenic mouse model of Alzheimer's disease." @default.
- W2077224993 created "2016-06-24" @default.
- W2077224993 creator A5024302106 @default.
- W2077224993 creator A5033498789 @default.
- W2077224993 creator A5048145081 @default.
- W2077224993 creator A5051449882 @default.
- W2077224993 creator A5056246750 @default.
- W2077224993 creator A5073568638 @default.
- W2077224993 creator A5078576975 @default.
- W2077224993 creator A5087664421 @default.
- W2077224993 date "2012-07-01" @default.
- W2077224993 modified "2023-10-01" @default.
- W2077224993 title "Long-term naringin consumption reverses a glucose uptake defect and improves cognitive deficits in a mouse model of Alzheimer's disease" @default.
- W2077224993 cites W1492443634 @default.
- W2077224993 cites W152142312 @default.
- W2077224993 cites W1776526278 @default.
- W2077224993 cites W1970293963 @default.
- W2077224993 cites W1973203723 @default.
- W2077224993 cites W1976219141 @default.
- W2077224993 cites W1978046076 @default.
- W2077224993 cites W1980542913 @default.
- W2077224993 cites W1981654394 @default.
- W2077224993 cites W1986733770 @default.
- W2077224993 cites W1988605096 @default.
- W2077224993 cites W1989120346 @default.
- W2077224993 cites W1989199176 @default.
- W2077224993 cites W1990867963 @default.
- W2077224993 cites W1995341268 @default.
- W2077224993 cites W1996032125 @default.
- W2077224993 cites W1997177821 @default.
- W2077224993 cites W2003721045 @default.
- W2077224993 cites W2004682362 @default.
- W2077224993 cites W2005719973 @default.
- W2077224993 cites W2007356331 @default.
- W2077224993 cites W2009576287 @default.
- W2077224993 cites W2012620585 @default.
- W2077224993 cites W2026587111 @default.
- W2077224993 cites W2031102482 @default.
- W2077224993 cites W2031659772 @default.
- W2077224993 cites W2032194353 @default.
- W2077224993 cites W2032960831 @default.
- W2077224993 cites W2034006321 @default.
- W2077224993 cites W2034664059 @default.
- W2077224993 cites W2039229967 @default.
- W2077224993 cites W2039266320 @default.
- W2077224993 cites W2046209489 @default.
- W2077224993 cites W2048221764 @default.
- W2077224993 cites W2050485762 @default.
- W2077224993 cites W2052104903 @default.
- W2077224993 cites W2053791137 @default.
- W2077224993 cites W2054183594 @default.
- W2077224993 cites W2055753122 @default.
- W2077224993 cites W2058221507 @default.
- W2077224993 cites W2058723245 @default.
- W2077224993 cites W2063354944 @default.
- W2077224993 cites W2070997349 @default.
- W2077224993 cites W2074508780 @default.
- W2077224993 cites W2076531205 @default.
- W2077224993 cites W2079206376 @default.
- W2077224993 cites W2080274663 @default.
- W2077224993 cites W2082446434 @default.
- W2077224993 cites W2083556882 @default.
- W2077224993 cites W2083633251 @default.
- W2077224993 cites W2084265646 @default.
- W2077224993 cites W2086233878 @default.
- W2077224993 cites W2087572489 @default.
- W2077224993 cites W2104852718 @default.
- W2077224993 cites W2105385589 @default.
- W2077224993 cites W2113814333 @default.
- W2077224993 cites W2114563246 @default.
- W2077224993 cites W2115474152 @default.
- W2077224993 cites W2124867155 @default.
- W2077224993 cites W2125553122 @default.
- W2077224993 cites W2125657871 @default.
- W2077224993 cites W2129176808 @default.
- W2077224993 cites W2135654319 @default.
- W2077224993 cites W2141644343 @default.
- W2077224993 cites W2143188708 @default.
- W2077224993 cites W2146187080 @default.
- W2077224993 cites W2146188406 @default.
- W2077224993 cites W2156275187 @default.
- W2077224993 cites W2157923070 @default.
- W2077224993 cites W2170246294 @default.
- W2077224993 cites W2171776741 @default.
- W2077224993 cites W2177900183 @default.
- W2077224993 cites W62299013 @default.
- W2077224993 doi "https://doi.org/10.1016/j.pbb.2012.03.013" @default.
- W2077224993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22741174" @default.
- W2077224993 hasPublicationYear "2012" @default.
- W2077224993 type Work @default.
- W2077224993 sameAs 2077224993 @default.
- W2077224993 citedByCount "46" @default.
- W2077224993 countsByYear W20772249932013 @default.
- W2077224993 countsByYear W20772249932014 @default.
- W2077224993 countsByYear W20772249932015 @default.
- W2077224993 countsByYear W20772249932016 @default.
- W2077224993 countsByYear W20772249932017 @default.
- W2077224993 countsByYear W20772249932018 @default.