FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077237687> ?p ?o ?g. }

• W2077237687 endingPage "12467" @default.
• W2077237687 startingPage "12462" @default.
• W2077237687 abstract "Radiolabeled peptides hold promise as diagnostic/therapeutic targeting vectors for specific human cancers. We report the design and development of a targeting vector, [(64)Cu-NOTA-8-Aoc-BBN(7-14)NH(2)] (NOTA = 1,4,7-triazacyclononane-1,4,7-triacetic acid, 8-Aoc = 8-aminooctanoic acid, and BBN = bombesin), having very high selectivity and affinity for the gastrin-releasing peptide receptor (GRPr). GRPrs are expressed on a variety of human cancers, including breast, lung, pancreatic, and prostate, making this a viable approach toward site-directed localization or therapy of these human diseases. In this study, [NOTA-X-BBN(7-14)NH(2)] conjugates were synthesized, where X = a specific pharmacokinetic modifier. The IC(50) of [NOTA-8-Aoc-BBN(7-14)NH(2)] was determined by a competitive displacement cell-binding assay in PC-3 human prostate cancer cells using (125)I-[Tyr(4)]-BBN as the displacement ligand. An IC(50) of 3.1 +/- 0.5 nM was obtained, demonstrating high binding affinity of [NOTA-8-Aoc-BBN] for the GRPr. [(64)Cu-NOTA-X-BBN] conjugates were prepared by the reaction of (64)CuCl(2) with peptides in buffered aqueous solution. In vivo studies of [(64)Cu-NOTA-8-Aoc-BBN(7-14)NH(2)] in tumor-bearing PC-3 mouse models indicated very high affinity of conjugate for the GRPr. Uptake of conjugate in tumor was 3.58 +/- 0.70% injected dose (ID) per g at 1 h postintravenous injection (p.i.). Minimal accumulation of radioactivity in liver tissue (1.58 +/- 0.40% ID per g, 1 h p.i.) is indicative of rapid renal-urinary excretion and suggests very high in vivo kinetic stability of [(64)Cu-NOTA-8-Aoc-BBN(7-14)NH(2)] with little or no in vivo dissociation of (64)Cu(2+) from the NOTA chelator. Kidney accumulation at 1 h p.i. was 3.79 +/- 1.09% ID per g. Molecular imaging studies in GRPr-expressing tumor models produced high-contrast, high-quality micro-positron-emission tomography images." @default.
• W2077237687 created "2016-06-24" @default.
• W2077237687 creator A5000842971 @default.
• W2077237687 creator A5010789813 @default.
• W2077237687 creator A5014582607 @default.
• W2077237687 creator A5015249456 @default.
• W2077237687 creator A5029015158 @default.
• W2077237687 creator A5040779098 @default.
• W2077237687 creator A5057721587 @default.
• W2077237687 creator A5060628443 @default.
• W2077237687 creator A5066471220 @default.
• W2077237687 creator A5089311593 @default.
• W2077237687 date "2007-07-24" @default.
• W2077237687 modified "2023-10-18" @default.
• W2077237687 title "[ ⁶⁴ Cu-NOTA-8-Aoc-BBN(7-14)NH ₂ ] targeting vector for positron-emission tomography imaging of gastrin-releasing peptide receptor-expressing tissues" @default.
• W2077237687 cites W1820294838 @default.
• W2077237687 cites W1861064994 @default.
• W2077237687 cites W1955439486 @default.
• W2077237687 cites W1963729543 @default.
• W2077237687 cites W1975737622 @default.
• W2077237687 cites W1978242745 @default.
• W2077237687 cites W1978402006 @default.
• W2077237687 cites W1981888695 @default.
• W2077237687 cites W1981942027 @default.
• W2077237687 cites W2000357234 @default.
• W2077237687 cites W2001885738 @default.
• W2077237687 cites W2007446708 @default.
• W2077237687 cites W2016454997 @default.
• W2077237687 cites W2020089212 @default.
• W2077237687 cites W2023687344 @default.
• W2077237687 cites W2023911605 @default.
• W2077237687 cites W2024426658 @default.
• W2077237687 cites W2041806531 @default.
• W2077237687 cites W2046214723 @default.
• W2077237687 cites W2051472477 @default.
• W2077237687 cites W2053344913 @default.
• W2077237687 cites W2057406263 @default.
• W2077237687 cites W2058282282 @default.
• W2077237687 cites W2065361341 @default.
• W2077237687 cites W2074700584 @default.
• W2077237687 cites W2075248048 @default.
• W2077237687 cites W2083400626 @default.
• W2077237687 cites W2105255209 @default.
• W2077237687 cites W2115470717 @default.
• W2077237687 cites W2116290973 @default.
• W2077237687 cites W2122452293 @default.
• W2077237687 cites W2134049155 @default.
• W2077237687 cites W2152311660 @default.
• W2077237687 cites W2162740426 @default.
• W2077237687 cites W2166796054 @default.
• W2077237687 cites W2182956754 @default.
• W2077237687 cites W2266233882 @default.
• W2077237687 cites W2319769414 @default.
• W2077237687 cites W2413370117 @default.
• W2077237687 cites W2426467811 @default.
• W2077237687 cites W2950022964 @default.
• W2077237687 cites W2952965668 @default.
• W2077237687 cites W3136319256 @default.
• W2077237687 doi "https://doi.org/10.1073/pnas.0705347104" @default.
• W2077237687 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1914305" @default.
• W2077237687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17626788" @default.
• W2077237687 hasPublicationYear "2007" @default.
• W2077237687 type Work @default.
• W2077237687 sameAs 2077237687 @default.
• W2077237687 citedByCount "203" @default.
• W2077237687 countsByYear W20772376872012 @default.
• W2077237687 countsByYear W20772376872013 @default.
• W2077237687 countsByYear W20772376872014 @default.
• W2077237687 countsByYear W20772376872015 @default.
• W2077237687 countsByYear W20772376872016 @default.
• W2077237687 countsByYear W20772376872017 @default.
• W2077237687 countsByYear W20772376872018 @default.
• W2077237687 countsByYear W20772376872019 @default.
• W2077237687 countsByYear W20772376872020 @default.
• W2077237687 countsByYear W20772376872021 @default.
• W2077237687 countsByYear W20772376872022 @default.
• W2077237687 countsByYear W20772376872023 @default.
• W2077237687 crossrefType "journal-article" @default.
• W2077237687 hasAuthorship W2077237687A5000842971 @default.
• W2077237687 hasAuthorship W2077237687A5010789813 @default.
• W2077237687 hasAuthorship W2077237687A5014582607 @default.
• W2077237687 hasAuthorship W2077237687A5015249456 @default.
• W2077237687 hasAuthorship W2077237687A5029015158 @default.
• W2077237687 hasAuthorship W2077237687A5040779098 @default.
• W2077237687 hasAuthorship W2077237687A5057721587 @default.
• W2077237687 hasAuthorship W2077237687A5060628443 @default.
• W2077237687 hasAuthorship W2077237687A5066471220 @default.
• W2077237687 hasAuthorship W2077237687A5089311593 @default.
• W2077237687 hasBestOaLocation W20772376872 @default.
• W2077237687 hasConcept C116569031 @default.
• W2077237687 hasConcept C118303440 @default.
• W2077237687 hasConcept C121608353 @default.
• W2077237687 hasConcept C126322002 @default.
• W2077237687 hasConcept C134306372 @default.
• W2077237687 hasConcept C150903083 @default.
• W2077237687 hasConcept C153911025 @default.
• W2077237687 hasConcept C170493617 @default.
• W2077237687 hasConcept C185592680 @default.

• next