Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077245767> ?p ?o ?g. }
- W2077245767 endingPage "731" @default.
- W2077245767 startingPage "721" @default.
- W2077245767 abstract "The purpose of this work was to study the mechanistic pathways of degradation of polysorbates (PS) 20 and PS80 in parenteral formulations. The fate of PS in typical protein formulations was monitored and analyzed by a variety of methods, including 1H NMR, high-performance liquid chromatography/evaporative light scattering detection, and ultraviolet–visible spectroscopy. Oxidative degradation of PS in neat raw material was studied using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and headspace gas chromatography–mass spectrometry. TGA–DSC studies revealed that autoxidation via a radical mechanism is dominated by statistical random scission in PS20 and PS80. Thermal initiation of radical formation occurs at the polyoxyethylene (POE) as well as the olefin sites. In PS80, radical initiation at the olefinic site precedes initiation at the POE site, leading to modified degradation profile. Corresponding to these results, in aqueous formulations, a surge peroxide content was detected in PS20-containing samples and in higher concentrations in those containing PS80. Hydrolysis in aqueous formulations, as followed by 1H NMR, was found to have a half-life of 5 months at 40°C. On the basis of the obtained results, PSs degrade mainly via autoxidation and also via hydrolysis at higher temperatures. Further studies are required to investigate on potential effects of degradation on surface activity and protein stability in PS-containing formulations." @default.
- W2077245767 created "2016-06-24" @default.
- W2077245767 creator A5001809020 @default.
- W2077245767 creator A5024576792 @default.
- W2077245767 creator A5034646990 @default.
- W2077245767 creator A5035828502 @default.
- W2077245767 creator A5049118543 @default.
- W2077245767 creator A5049677312 @default.
- W2077245767 creator A5052151636 @default.
- W2077245767 date "2011-02-01" @default.
- W2077245767 modified "2023-10-18" @default.
- W2077245767 title "Degradation of Polysorbates 20 and 80: Studies on Thermal Autoxidation and Hydrolysis" @default.
- W2077245767 cites W1276324155 @default.
- W2077245767 cites W1602974455 @default.
- W2077245767 cites W1901346319 @default.
- W2077245767 cites W1975446929 @default.
- W2077245767 cites W1976948929 @default.
- W2077245767 cites W1984617885 @default.
- W2077245767 cites W1986397390 @default.
- W2077245767 cites W1986876623 @default.
- W2077245767 cites W1987985752 @default.
- W2077245767 cites W1988834123 @default.
- W2077245767 cites W1994123926 @default.
- W2077245767 cites W1994763065 @default.
- W2077245767 cites W2001087246 @default.
- W2077245767 cites W2005041125 @default.
- W2077245767 cites W2007825260 @default.
- W2077245767 cites W2009689400 @default.
- W2077245767 cites W2011496761 @default.
- W2077245767 cites W2017434735 @default.
- W2077245767 cites W2018182312 @default.
- W2077245767 cites W2027380058 @default.
- W2077245767 cites W2030450209 @default.
- W2077245767 cites W2034988099 @default.
- W2077245767 cites W2037525279 @default.
- W2077245767 cites W2039647080 @default.
- W2077245767 cites W2041723098 @default.
- W2077245767 cites W2044393380 @default.
- W2077245767 cites W2049703963 @default.
- W2077245767 cites W2054187364 @default.
- W2077245767 cites W2057317203 @default.
- W2077245767 cites W2058603345 @default.
- W2077245767 cites W2061480740 @default.
- W2077245767 cites W2068426104 @default.
- W2077245767 cites W2072398283 @default.
- W2077245767 cites W2076710204 @default.
- W2077245767 cites W2078843599 @default.
- W2077245767 cites W2081640562 @default.
- W2077245767 cites W2086137175 @default.
- W2077245767 cites W2089234877 @default.
- W2077245767 cites W2111877521 @default.
- W2077245767 cites W2112705402 @default.
- W2077245767 cites W2119269930 @default.
- W2077245767 cites W2144217084 @default.
- W2077245767 cites W2163058438 @default.
- W2077245767 cites W2167979409 @default.
- W2077245767 cites W4231506841 @default.
- W2077245767 doi "https://doi.org/10.1002/jps.22290" @default.
- W2077245767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20803573" @default.
- W2077245767 hasPublicationYear "2011" @default.
- W2077245767 type Work @default.
- W2077245767 sameAs 2077245767 @default.
- W2077245767 citedByCount "213" @default.
- W2077245767 countsByYear W20772457672012 @default.
- W2077245767 countsByYear W20772457672013 @default.
- W2077245767 countsByYear W20772457672014 @default.
- W2077245767 countsByYear W20772457672015 @default.
- W2077245767 countsByYear W20772457672016 @default.
- W2077245767 countsByYear W20772457672017 @default.
- W2077245767 countsByYear W20772457672018 @default.
- W2077245767 countsByYear W20772457672019 @default.
- W2077245767 countsByYear W20772457672020 @default.
- W2077245767 countsByYear W20772457672021 @default.
- W2077245767 countsByYear W20772457672022 @default.
- W2077245767 countsByYear W20772457672023 @default.
- W2077245767 crossrefType "journal-article" @default.
- W2077245767 hasAuthorship W2077245767A5001809020 @default.
- W2077245767 hasAuthorship W2077245767A5024576792 @default.
- W2077245767 hasAuthorship W2077245767A5034646990 @default.
- W2077245767 hasAuthorship W2077245767A5035828502 @default.
- W2077245767 hasAuthorship W2077245767A5049118543 @default.
- W2077245767 hasAuthorship W2077245767A5049677312 @default.
- W2077245767 hasAuthorship W2077245767A5052151636 @default.
- W2077245767 hasBestOaLocation W20772457671 @default.
- W2077245767 hasConcept C121332964 @default.
- W2077245767 hasConcept C178790620 @default.
- W2077245767 hasConcept C184651966 @default.
- W2077245767 hasConcept C185592680 @default.
- W2077245767 hasConcept C2779679103 @default.
- W2077245767 hasConcept C37329643 @default.
- W2077245767 hasConcept C39519442 @default.
- W2077245767 hasConcept C41008148 @default.
- W2077245767 hasConcept C43617362 @default.
- W2077245767 hasConcept C521977710 @default.
- W2077245767 hasConcept C60100273 @default.
- W2077245767 hasConcept C63179538 @default.
- W2077245767 hasConcept C76155785 @default.
- W2077245767 hasConcept C94412978 @default.