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• W2077251489 abstract "<b>Background: </b> Painful sensory neuropathy is a common complication of HIV infection. Based on prior uncontrolled observations, we hypothesized that amitriptyline or mexiletine would improve the pain symptoms. <b>Method: </b> A randomized, double-blind, 10-week trial of 145 patients assigned equally to amitriptyline, mexiletine, or matching placebo. The primary outcome measure was the change in pain intensity between baseline and the final visit. <b>Results: </b> The improvement in amitriptyline group (0.31 ± 0.31 units [mean ± SD]) and mexiletine group (0.23 ± 0.41) was not significantly different from placebo (0.20 ± 0.30). Both interventions were generally well tolerated. <b>Conclusions: </b> Neither amitriptyline nor mexiletine provide significant pain relief in patients with HIV-associated painful sensory neuropathy." @default.
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• W2077251489 date "2004-05-01" @default.
• W2077251489 modified "2023-09-27" @default.
• W2077251489 title "Secondary transport of the critically ill and injured adult" @default.
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• W2077251489 doi "https://doi.org/10.1136/emj.2003.005975" @default.
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