Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077257612> ?p ?o ?g. }
- W2077257612 endingPage "434" @default.
- W2077257612 startingPage "428" @default.
- W2077257612 abstract "Elevated interstitial fluid pressure (IFP) in a tumor is a barrier to tumor accumulation of systemic delivery of nanocarriers. In this study, we investigated whether intravenous injection of type I collagenase (collagenase-1) reduced IFP in tumors and increased the accumulation and gene expression of cationic liposome/plasmid DNA complex (lipoplex) in tumors after intravenous injection into mice bearing mouse lung carcinoma LLC tumors. Collagenase-1 reduced the amount of type I collagen in the tumor, and significantly decreased IFP by 65% at 1 h after injection. Therefore, collagenase-1 induced 1.5-fold higher accumulation and 2-fold higher gene expression of lipoplex in tumors after intravenous injection. These findings indicated that intravenous injection of collagenase-1 improved the accumulation of lipoplex by decreasing IFP in tumors. These results support the potential use of collagen digestion as a strategy to improve systemic gene delivery into tumors." @default.
- W2077257612 created "2016-06-24" @default.
- W2077257612 creator A5038246750 @default.
- W2077257612 creator A5047674608 @default.
- W2077257612 creator A5061906026 @default.
- W2077257612 creator A5066533435 @default.
- W2077257612 date "2012-02-01" @default.
- W2077257612 modified "2023-09-25" @default.
- W2077257612 title "Collagenase-1 injection improved tumor distribution and gene expression of cationic lipoplex" @default.
- W2077257612 cites W1791657458 @default.
- W2077257612 cites W1872991389 @default.
- W2077257612 cites W1965001670 @default.
- W2077257612 cites W1967470122 @default.
- W2077257612 cites W1975901472 @default.
- W2077257612 cites W1980661188 @default.
- W2077257612 cites W1981931991 @default.
- W2077257612 cites W1985957186 @default.
- W2077257612 cites W1990983926 @default.
- W2077257612 cites W2001658518 @default.
- W2077257612 cites W2028156849 @default.
- W2077257612 cites W2041492502 @default.
- W2077257612 cites W2042172115 @default.
- W2077257612 cites W2067765575 @default.
- W2077257612 cites W2071531515 @default.
- W2077257612 cites W2099853494 @default.
- W2077257612 cites W2099887788 @default.
- W2077257612 cites W2107338023 @default.
- W2077257612 cites W2117243396 @default.
- W2077257612 cites W2120372571 @default.
- W2077257612 cites W2130541509 @default.
- W2077257612 cites W2132467763 @default.
- W2077257612 cites W2145312678 @default.
- W2077257612 cites W2172298636 @default.
- W2077257612 doi "https://doi.org/10.1016/j.ijpharm.2011.12.015" @default.
- W2077257612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22197775" @default.
- W2077257612 hasPublicationYear "2012" @default.
- W2077257612 type Work @default.
- W2077257612 sameAs 2077257612 @default.
- W2077257612 citedByCount "66" @default.
- W2077257612 countsByYear W20772576122012 @default.
- W2077257612 countsByYear W20772576122013 @default.
- W2077257612 countsByYear W20772576122014 @default.
- W2077257612 countsByYear W20772576122015 @default.
- W2077257612 countsByYear W20772576122016 @default.
- W2077257612 countsByYear W20772576122017 @default.
- W2077257612 countsByYear W20772576122018 @default.
- W2077257612 countsByYear W20772576122019 @default.
- W2077257612 countsByYear W20772576122020 @default.
- W2077257612 countsByYear W20772576122021 @default.
- W2077257612 countsByYear W20772576122022 @default.
- W2077257612 countsByYear W20772576122023 @default.
- W2077257612 crossrefType "journal-article" @default.
- W2077257612 hasAuthorship W2077257612A5038246750 @default.
- W2077257612 hasAuthorship W2077257612A5047674608 @default.
- W2077257612 hasAuthorship W2077257612A5061906026 @default.
- W2077257612 hasAuthorship W2077257612A5066533435 @default.
- W2077257612 hasConcept C104317684 @default.
- W2077257612 hasConcept C111599444 @default.
- W2077257612 hasConcept C135983454 @default.
- W2077257612 hasConcept C150194340 @default.
- W2077257612 hasConcept C153911025 @default.
- W2077257612 hasConcept C155887181 @default.
- W2077257612 hasConcept C181199279 @default.
- W2077257612 hasConcept C185592680 @default.
- W2077257612 hasConcept C2778394429 @default.
- W2077257612 hasConcept C502942594 @default.
- W2077257612 hasConcept C55493867 @default.
- W2077257612 hasConcept C86803240 @default.
- W2077257612 hasConceptScore W2077257612C104317684 @default.
- W2077257612 hasConceptScore W2077257612C111599444 @default.
- W2077257612 hasConceptScore W2077257612C135983454 @default.
- W2077257612 hasConceptScore W2077257612C150194340 @default.
- W2077257612 hasConceptScore W2077257612C153911025 @default.
- W2077257612 hasConceptScore W2077257612C155887181 @default.
- W2077257612 hasConceptScore W2077257612C181199279 @default.
- W2077257612 hasConceptScore W2077257612C185592680 @default.
- W2077257612 hasConceptScore W2077257612C2778394429 @default.
- W2077257612 hasConceptScore W2077257612C502942594 @default.
- W2077257612 hasConceptScore W2077257612C55493867 @default.
- W2077257612 hasConceptScore W2077257612C86803240 @default.
- W2077257612 hasFunder F4320320912 @default.
- W2077257612 hasIssue "2" @default.
- W2077257612 hasLocation W20772576121 @default.
- W2077257612 hasLocation W20772576122 @default.
- W2077257612 hasOpenAccess W2077257612 @default.
- W2077257612 hasPrimaryLocation W20772576121 @default.
- W2077257612 hasRelatedWork W1991379144 @default.
- W2077257612 hasRelatedWork W2035021059 @default.
- W2077257612 hasRelatedWork W2100253500 @default.
- W2077257612 hasRelatedWork W2142802916 @default.
- W2077257612 hasRelatedWork W2334197066 @default.
- W2077257612 hasRelatedWork W2411191908 @default.
- W2077257612 hasRelatedWork W2411976036 @default.
- W2077257612 hasRelatedWork W2412373422 @default.
- W2077257612 hasRelatedWork W2957788206 @default.
- W2077257612 hasRelatedWork W384502178 @default.
- W2077257612 hasVolume "423" @default.
- W2077257612 isParatext "false" @default.