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- W2077257987 abstract "Interferon (IFN)-α and IFN-β (“type I” IFNs), but not IFN-γ reduced phytohemagglutininor pokeweed mitogen (PWM)-induced proliferation in cultures of human mononuclear leukocytes. Proliferation induced by specific antigens (tuberculin PPD or tetanus toxoid) or by exogenous interleukin 2 (IL-2) was strongly inhibited by type I IFNs and, to a lesser extent, by IFN-γ as well. Inhibition of proliferation in mitogen-stimulated cultures was not due to a reduced production of IL-2 or to an inhibition of IL-2 receptor expression. Type I IFNs inhibited immunoglobulin (Ig) production in PWM-stimulated unseparated mononuclear cells, whereas IFN-γ enhanced Ig production in such cultures. In cultures of purified B cells type I IFNs caused a stimulation of Ig production and this B-cell differentiation factor (BCDF) hike activity of IFNs was synergistically enhanced in the presence of IL-2. IFN-γ produced less BCDF-like activity than type I IFNs. These results show that in some instances type I IFNs can be more potent in affecting functions of cells of the immune system than IFN-γ." @default.
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- W2077257987 date "1986-09-01" @default.
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- W2077257987 title "Modulation of lymphocyte proliferation and immunoglobulin synthesis by interferon-γ and “type I” interferons" @default.
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- W2077257987 doi "https://doi.org/10.1016/0008-8749(86)90151-6" @default.
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