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• W2077259639 abstract "We used pharmacological agents and genetic methods to determine whether the potent A₃ adenosine receptor (AR) agonist 2-chloro-<i>N</i>⁶-(3-iodobenzyl)adenosine-5′-<i>N</i>-methylcarboxamide (Cl-IB-MECA) protects against myocardial ischemia/reperfusion injury in mice via the A₃AR or via interactions with other AR subtypes. Pretreating wild-type (WT) mice with Cl-IB-MECA reduced myocardial infarct size induced by 30 min of coronary occlusion and 24 h of reperfusion at doses (30 and 100 μg/kg) that concomitantly reduced blood pressure and stimulated systemic histamine release. The A₃AR-selective antagonist MRS 1523 [3-propyl-6-ethyl-5[(ethylthio)carbonyl]-2-phenyl-4-propyl-3-pyridine-carboxylate], but not the A_2AAR antagonist ZM 241385 [4-{2-7-amino-2-(2-furyl)[1,2,4]triazolo-[2,3-<i>a</i>][1,3,5]triazin-5-ylamino]ethyl}phenol], blocked the reduction in infarct size provided by Cl-IB-MECA, suggesting a mechanism involving the A₃AR. To further examine the selectivity of Cl-IB-MECA, we assessed its cardioprotective effectiveness in A₃AR gene “knock-out” (A₃KO) mice. Cl-IB-MECA did not reduce myocardial infarct size in A₃KO mice in vivo and did not protect isolated perfused hearts obtained from A₃KO mice from injury induced by global ischemia and reperfusion. Additional studies using WT mice treated with compound 48/80 [condensation product of <i>p</i>-methoxyphenethyl methylamine with formaldehyde] to deplete mast cell contents excluded the possibility that Cl-IB-MECA was cardioprotective by releasing mediators from mast cells. These data demonstrate that Cl-IB-MECA protects against myocardial ischemia/reperfusion injury in mice principally by activating the A₃AR." @default.
• W2077259639 created "2016-06-24" @default.
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• W2077259639 date "2006-09-19" @default.
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• W2077259639 title "Cl-IB-MECA [2-Chloro-<i>N</i>⁶-(3-iodobenzyl)adenosine-5′-<i>N</i>-methylcarboxamide] Reduces Ischemia/Reperfusion Injury in Mice by Activating the A Adenosine Receptor" @default.
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• W2077259639 doi "https://doi.org/10.1124/jpet.106.111351" @default.
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