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- W2077263385 endingPage "556" @default.
- W2077263385 startingPage "544" @default.
- W2077263385 abstract "Although human studies have emphasized a role for IL-2 in depressive illness, limited attention has been devoted to the behavioral and neurochemical effects of this cytokine in animal studies. The present review assesses the behavioral effects of IL-2 in rodents, in counterpoint to the effects of interleukin-1beta (IL-1beta), necrosis factor-alpha (TNF-alpha) and endotoxin challenge. Unlike IL-1beta, systemic IL-2 provokes modest effects on hypothalamic-pituitary-adrenal (HPA) functioning, and does not provoke marked signs of illness or anxiety. In some respects, however, IL-2 elicits effects reminiscent of traditional stressors, including anhedonia (diminished pleasure gained from otherwise rewarding stimuli). Additionally, when chronically administered, IL-2 may impact on cognitive processes, including spatial working memory. While IL-2 may induce depressive-like symptoms, the available data are sparse, have hardly considered the impact of chronic cytokine treatment, only assessed behavior in a narrow range of tests, and it remains to be established whether the effects of IL-2 are modifiable by antidepressant treatments. Finally, as the effects of IL-2 on CNS processes vary in a biphasic fashion, and may also engender neurotoxic effects, further analyses are necessary to discern under what conditions this cytokine provokes depressive-like behavioral outcomes." @default.
- W2077263385 created "2016-06-24" @default.
- W2077263385 creator A5027246988 @default.
- W2077263385 creator A5036903722 @default.
- W2077263385 creator A5058574287 @default.
- W2077263385 date "2002-10-01" @default.
- W2077263385 modified "2023-10-06" @default.
- W2077263385 title "Further evidence for the depressive effects of cytokines: Anhedonia and neurochemical changes" @default.
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