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• W2077266191 startingPage "756" @default.
• W2077266191 abstract "Derived from adrenal cortical, dehydroepiandrosterone-sulfate (DHEAS) is a precursor to androgens and estrogens, with various bioactivities. Although it has the property of anti-diabetes, the long-term effect of DHEAS on insulin secretion in beta-cells is still unclear. In this study, the effect of DHEAS on the insulin secretion activity in MIN6 cell lines in vitro was assessed. Insulin biosynthesis and secretion were stimulated by DHEAS for 24 h. DHEAS inhibited the AMPK activation and upregulated the expression of ACC-1. These findings indicate that DHEAS may exert prominent stimulatory effects on insulin secretion partly via AMPK inhibition and ACC-1 upregulation." @default.
• W2077266191 created "2016-06-24" @default.
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• W2077266191 date "2013-11-01" @default.
• W2077266191 modified "2023-10-16" @default.
• W2077266191 title "Dehydroepiandrosterone-sulfate (DHEAS) promotes MIN6 cells insulin secretion via inhibition of AMP-activated protein kinase" @default.
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• W2077266191 doi "https://doi.org/10.1016/j.bbrc.2013.10.002" @default.
• W2077266191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24120945" @default.
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