FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077269712> ?p ?o ?g. }

• W2077269712 endingPage "440" @default.
• W2077269712 startingPage "434" @default.
• W2077269712 abstract "Early developmental insults can cause dysfunction within parvalbumin (PVB)-containing interneurons in the prefrontal cortex. The neuropsychiatric disorders associated with such dysfunction might involve neuroinflammatory processes. Cyclooxygenase-2 (COX-2) is a key mediator of inflammation and is therefore a potential target for preventive treatment. Here, we investigated whether the developmental trajectories of PVB expression and COX-2 induction in the prelimbic region of the prefrontal cortex are altered after maternal separation stress in male rats.Male rat pups were separated from their mother and littermates for 4 hours/day between postnatal Days 2 and 20. Western blotting and immunohistochemistry were used to analyze PVB and COX-2 expression in the prefrontal cortex and hippocampus. A separate cohort of animals was treated with a COX-2 inhibitor during preadolescence and analyzed for PVB, COX-2, and working memory performance.We demonstrate that maternal separation causes a reduction of PVB and an increase in COX-2 expression in the prefrontal cortex in adolescence, with concurrent working memory deficits. Parvalbumin was not affected earlier in development. Prophylactic COX-2 inhibition preadolescence prevents PVB loss and improves working memory deficits induced by maternal separation.These data are the first to show a preventive pharmacological intervention for the delayed effects of early life stress on prefrontal cortex interneurons and working memory. Our results suggest a possible mechanism for the relationship between early life stress and interneuron dysfunction in adolescence." @default.
• W2077269712 created "2016-06-24" @default.
• W2077269712 creator A5012854700 @default.
• W2077269712 creator A5028983848 @default.
• W2077269712 date "2011-09-01" @default.
• W2077269712 modified "2023-09-28" @default.
• W2077269712 title "Nonsteroidal Anti-Inflammatory Treatment Prevents Delayed Effects of Early Life Stress in Rats" @default.
• W2077269712 cites W1547358456 @default.
• W2077269712 cites W1572495684 @default.
• W2077269712 cites W1973284861 @default.
• W2077269712 cites W1977678115 @default.
• W2077269712 cites W1979418246 @default.
• W2077269712 cites W1980265366 @default.
• W2077269712 cites W1981453653 @default.
• W2077269712 cites W1984003649 @default.
• W2077269712 cites W1984427714 @default.
• W2077269712 cites W1987375729 @default.
• W2077269712 cites W1987709429 @default.
• W2077269712 cites W1990366708 @default.
• W2077269712 cites W1993259058 @default.
• W2077269712 cites W1996885013 @default.
• W2077269712 cites W1998973288 @default.
• W2077269712 cites W1999107021 @default.
• W2077269712 cites W2002643558 @default.
• W2077269712 cites W2004497754 @default.
• W2077269712 cites W2005744000 @default.
• W2077269712 cites W2007116375 @default.
• W2077269712 cites W2008537040 @default.
• W2077269712 cites W2009252034 @default.
• W2077269712 cites W2009887240 @default.
• W2077269712 cites W2015884970 @default.
• W2077269712 cites W2017181469 @default.
• W2077269712 cites W2022809683 @default.
• W2077269712 cites W2023144165 @default.
• W2077269712 cites W2027832398 @default.
• W2077269712 cites W2028385892 @default.
• W2077269712 cites W2030028265 @default.
• W2077269712 cites W2030538289 @default.
• W2077269712 cites W2032516641 @default.
• W2077269712 cites W2032572756 @default.
• W2077269712 cites W2040087969 @default.
• W2077269712 cites W2041068600 @default.
• W2077269712 cites W2042947853 @default.
• W2077269712 cites W2047559277 @default.
• W2077269712 cites W2049319643 @default.
• W2077269712 cites W2050035705 @default.
• W2077269712 cites W2059022502 @default.
• W2077269712 cites W2059656229 @default.
• W2077269712 cites W2062574700 @default.
• W2077269712 cites W2067908853 @default.
• W2077269712 cites W2068366261 @default.
• W2077269712 cites W2071196441 @default.
• W2077269712 cites W2073983299 @default.
• W2077269712 cites W2077473360 @default.
• W2077269712 cites W2078318286 @default.
• W2077269712 cites W2079599824 @default.
• W2077269712 cites W2082569011 @default.
• W2077269712 cites W2085139678 @default.
• W2077269712 cites W2086931186 @default.
• W2077269712 cites W2086936738 @default.
• W2077269712 cites W2089912569 @default.
• W2077269712 cites W2091987951 @default.
• W2077269712 cites W2099201877 @default.
• W2077269712 cites W2103089294 @default.
• W2077269712 cites W2112148221 @default.
• W2077269712 cites W2115762181 @default.
• W2077269712 cites W2123290069 @default.
• W2077269712 cites W2126457554 @default.
• W2077269712 cites W2133199972 @default.
• W2077269712 cites W2136757585 @default.
• W2077269712 cites W2144859742 @default.
• W2077269712 cites W2148399921 @default.
• W2077269712 cites W2150255019 @default.
• W2077269712 cites W2157151225 @default.
• W2077269712 cites W2157456455 @default.
• W2077269712 cites W2161143338 @default.
• W2077269712 cites W2166670920 @default.
• W2077269712 cites W2170328434 @default.
• W2077269712 cites W2170696995 @default.
• W2077269712 cites W2170990401 @default.
• W2077269712 cites W2324419367 @default.
• W2077269712 cites W2332934002 @default.
• W2077269712 doi "https://doi.org/10.1016/j.biopsych.2011.05.006" @default.
• W2077269712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5237809" @default.
• W2077269712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21679927" @default.
• W2077269712 hasPublicationYear "2011" @default.
• W2077269712 type Work @default.
• W2077269712 sameAs 2077269712 @default.
• W2077269712 citedByCount "108" @default.
• W2077269712 countsByYear W20772697122012 @default.
• W2077269712 countsByYear W20772697122013 @default.
• W2077269712 countsByYear W20772697122014 @default.
• W2077269712 countsByYear W20772697122015 @default.
• W2077269712 countsByYear W20772697122016 @default.
• W2077269712 countsByYear W20772697122017 @default.
• W2077269712 countsByYear W20772697122018 @default.
• W2077269712 countsByYear W20772697122019 @default.
• W2077269712 countsByYear W20772697122020 @default.

• next