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- W2077269827 abstract "The study was designed to assess the antihypertensive effect of combined angiotensin converting enzyme (ACE) inhibition and angiotensin II type 1 receptor (AT1) antagonism in patients with essential hypertension. Twenty patients with uncontrolled ambulatory diastolic blood pressure (BP) after 6 weeks on benazepril monotherapy at 20 mg o.d. were randomized to receive double-blind valsartan 80 mg o.d. or matching placebo for 5 weeks while continuing to receive background benazepril. Then patients crossed-over to the alternative regimen for a second 5-week period. 24-hour ambulatory BP was monitored on the final day of the benazepril monotherapy period and on the final day of each double-blind treatment period. Valsartan added to benazepril produced a significant antihypertensive effect with a benefit over placebo of 6.5 ± 12.6/4.5 ± 8.0 mmHg (systolic/diastolic) for average awake ambulatory BP (p < 0.05), 7.1 ± 9.4/5.6 ± 6.5 for asleep BP (p < 0.01), and 6.8 ± 9.7/4.9 ± 6.8 for average 24-hour ambulatory BP (p < 0.01). Pulse rate was unaffected. Plasma active renin was higher on the benazepril-valsartan combination compared to benazepril-placebo (p < 0.05). There was no change in routine biochemical variables when valsartan was added to benazepril. Six patients reported mild dizziness or fatigue (3 also on placebo). These data suggest that in hypertensive patients uncontrolled on an ACE inhibitor the addition of an AT1 antagonist provides a powerful and safe antihypertensive drug combination." @default.
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- W2077269827 date "2000-06-01" @default.
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- W2077269827 title "Additive hypotensive effect of angiotensin converting enzyme inhibition and angiotensin receptor antagonism in essential hypertension" @default.
- W2077269827 doi "https://doi.org/10.1016/s0895-7061(00)00538-0" @default.
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