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• W2077271225 startingPage "71" @default.
• W2077271225 abstract "Lysophosphatidylcholine (lysoPC) is implicated in the development of atherosclerosis and certain autoimmune diseases, and is reported to induce tissue-type plasminogen activator (tPA) at the protein level in endothelial cells. This study was designed to investigate the effect of lysoPC on tPA gene expression and the underlying molecular mechanisms in cultured endothelial cells. LysoPC transiently induced the mRNA expression of tPA in endothelial cells. LysoPC also induced the mRNA expression of urokinase-type plasminogen activator (uPA), uPA receptor, and plasminogen activator inhibitor-1, but the kinetics were different from that of tPA. Promoter analysis revealed that the cyclic AMP-responsive element of the tPA gene (tPACRE) is required for lysoPC-induced tPA expression. Furthermore, an electrophoresis mobility shift assay showed that lysoPC increased the binding activity of CRE binding protein to tPACRE. These results indicated that lysoPC transcriptionally upregulated the gene expression of tPA in endothelial cells, at least in part, via tPACRE activation." @default.
• W2077271225 created "2016-06-24" @default.
• W2077271225 creator A5035137570 @default.
• W2077271225 creator A5044487444 @default.
• W2077271225 creator A5085215011 @default.
• W2077271225 date "2005-04-01" @default.
• W2077271225 modified "2023-09-27" @default.
• W2077271225 title "Lysophosphatidylcholine induces tPA gene expression through CRE-dependent mechanism" @default.
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• W2077271225 doi "https://doi.org/10.1016/j.bbrc.2005.01.094" @default.
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• W2077271225 hasPublicationYear "2005" @default.
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