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- W2077271792 abstract "Physiological and pathological processes within the human body are controlled by complex cell-cell interactions within the context of a dynamic microenvironment. Current methods are inadequate to monitor the multiple interactions and dissect the contributions of single cells to these processes. We will present the development of nanoprobes based on nanopipettes for manipulating living cells. We will describe the integration of these nanoprobes with scanning probe microscopy techniques to allow the delivery of biomolecules to individual cells and to biopsy minute amounts of cytoplasmic material and organelles from within living cells. In particular, we will discuss recent developments regarding the fabrication of carbon nanoelectrodes whose size can be precisely tuned with nanometer precision. Nanoelectrodes as small as 3 nm in radius can be functionalized with platinum using established electrochemical methods. The electrochemical deposition of platinum only slightly increases the surface area of the nanoelectrode but dramatically enhances its catalytic activity toward oxygen reduction and hydrogen peroxide oxidation. We will discuss their application for measurement of metabolic activity inside brain slices. Furthermore, the nanoelectrode can be precisely inserted into an individual neuron within the brain tissue with minimal disturbance to the biological milieu. We will present data showing the ability of the functionalized nanoelectrodes to measure intracellular endogenous molecules. Current studies in our group are trying to link the measured current with pathogenic conditions." @default.
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- W2077271792 date "2014-01-01" @default.
- W2077271792 modified "2023-09-29" @default.
- W2077271792 title "Tailoring Nanoprobes for Single-Cell Surgery" @default.
- W2077271792 doi "https://doi.org/10.1016/j.bpj.2013.11.2332" @default.
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