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- W2077277741 endingPage "431" @default.
- W2077277741 startingPage "419" @default.
- W2077277741 abstract "Hypervolemia and hyponatremia resulting from activation of the neurohormonal system and impairment of renal function are prominent features of decompensated heart failure. Both conditions share many pathophysiologic and prognostic features and each has been associated with increased morbidity and mortality. When both conditions coexist, therapeutic options are limited.This review presents a concise digest of the pathophysiology, clinical significance, and pharmacological therapy of hyponatremia complicating heart failure with a special emphasis on vasopressin antagonists and their aquaretic effects in the absence of neurohormonal activation along with their ability to correct hyponatremia.Hypervolemia and hyponatremia share many pathophysiologic and prognostic features in heart failure. Vasopressin antagonists provide a viable option for their management and a potentially unique role when both conditions coexists." @default.
- W2077277741 created "2016-06-24" @default.
- W2077277741 creator A5017806292 @default.
- W2077277741 creator A5077001178 @default.
- W2077277741 date "2010-05-01" @default.
- W2077277741 modified "2023-10-16" @default.
- W2077277741 title "The Critical Link of Hypervolemia and Hyponatremia in Heart Failure and the Potential Role of Arginine Vasopressin Antagonists" @default.
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