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• W2077277924 abstract "Use of current oral calcineurin inhibitors for the treatment of psoriasis is limited by toxicity.Evaluate the safety and efficacy of ISA247, a new oral calcineurin inhibitor, in plaque psoriasis patients.This 12-week, randomized, double-blind, placebo-controlled, parallel-group study included 201 plaque psoriasis patients with > or = 10% body surface area involvement. Patients were randomized to placebo, ISA247 0.5 mg/kg/d, and ISA247 1.5 mg/kg/d groups. End points included a 2-point reduction in the Static Global Assessment score and a 75% reduction in the Psoriasis Area and Severity Index.A 2-point SGA reduction was achieved in 0% (placebo), 15.6% (0.5 mg/kg/d), and 45.1% (1.5 mg/kg/d) (P < .0001). A 75% reduction in the Psoriasis Area and Severity Index was achieved in 0% (placebo), 18.2% (0.5 mg/kg/d), and 66.7% (1.5 mg/kg/day) (P < .0001). While serum creatinine increased in patients treated with ISA247 1.5 mg/kg/d, it remained within the normal range.Longer-term studies are needed to evaluate the effect of ISA247 on renal function.ISA247 appears safe and effective for treating moderate to severe psoriasis." @default.
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• W2077277924 date "2006-03-01" @default.
• W2077277924 modified "2023-10-18" @default.
• W2077277924 title "A randomized, multicenter, double-blind, placebo-controlled phase 2 trial of ISA247 in patients with chronic plaque psoriasis" @default.
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• W2077277924 doi "https://doi.org/10.1016/j.jaad.2005.10.061" @default.
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