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- W2077282297 abstract "The effect of daily administration of placebo or 200 or 500 mg. tablets of vitamin C on symptom association and on the incidence, duration, severity, and total intensity of the symptoms in the common cold has been studied. The metabolism of ascorbic acid during the common cold, and after disappearance of all the symptoms, has been investigated by examining the plasma and leucocyte ascorbic-acid concentrations after a loading dose of 500 mg. vitamin C. Cold symptoms tend to dissociate into toxic and catarrhal complexes, the complexity and frequency of which differ between boys and girls. Vitamin C reduces symptom association and alters the frequency of toxic and catarrhal complexes. It significantly reduces the severity and total intensity of colds in girls, but does not benefit cold symptoms in boys at a daily dose of 500 mg. During colds, especially of the catarrhal variety, ascorbic acid is transferred out of the leucocytes into the plasma, where it is rapidly metabolised in both sexes, but this effect is more pronounced in females. There is a significant positive correlation between metabolic utilisation of ascorbic acid during colds and intensity of cold symptoms." @default.
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- W2077282297 date "1973-03-01" @default.
- W2077282297 modified "2023-10-18" @default.
- W2077282297 title "COMMON COLD AND VITAMIN C" @default.
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- W2077282297 doi "https://doi.org/10.1016/s0140-6736(73)92202-2" @default.
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