FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077283409> ?p ?o ?g. }

• W2077283409 endingPage "24" @default.
• W2077283409 startingPage "11" @default.
• W2077283409 abstract "The frequency of reversions induced in Escherichia coli K-12 trpA58 by any of five different monofunctional alkylating agents increased as the growth rate of the organism was raised prior to mutagen treatment. The increase in mutation frequency did not correlate with growth rate-dependent changes in cell area or total cellular protein and DNA. After treatment of cells with N-methyl-N-nitrosourea (MNUA), no growth rate-dependent change was observed in the total DNA alkylation or percentage of O6-methylguanine present in the DNA extracted. The frequency of reversions induced by one mutagen, methyl methanesulphonate (MMS), increased in proportion to the average number of trpA gene copies per cell, whereas the frequency of reversions induced by the other compounds was dependent on the average number of chromosome replicating forks per cell. This difference was attributed to the different ratios of DNA base alkylation products observed, formed after treatment with MMS, an SN2-type reagent, or after treatment with the SN1-type reagents ethyl methanesulphonate (EMS), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), MNUA and N-ethyl-N-nitrosourea (ENUA). Possible reasons for the dependence of mutation frequency on the number of replicating forks per cell are discussed." @default.
• W2077283409 created "2016-06-24" @default.
• W2077283409 creator A5037093070 @default.
• W2077283409 creator A5065292122 @default.
• W2077283409 date "1977-04-01" @default.
• W2077283409 modified "2023-09-27" @default.
• W2077283409 title "Physiological modification of alkylating agent induced mutagenesis. II. Influence of the numbers of chromosome replicating forks and gene copies on the frequency of mutations induced in Escherichia coli" @default.
• W2077283409 cites W117841731 @default.
• W2077283409 cites W142271298 @default.
• W2077283409 cites W1485044984 @default.
• W2077283409 cites W1545203638 @default.
• W2077283409 cites W1614195876 @default.
• W2077283409 cites W1848310822 @default.
• W2077283409 cites W1906197854 @default.
• W2077283409 cites W1968048570 @default.
• W2077283409 cites W1969579867 @default.
• W2077283409 cites W1974078761 @default.
• W2077283409 cites W1982179268 @default.
• W2077283409 cites W1984214712 @default.
• W2077283409 cites W1986321542 @default.
• W2077283409 cites W1988691705 @default.
• W2077283409 cites W1998214800 @default.
• W2077283409 cites W1998247911 @default.
• W2077283409 cites W1999594874 @default.
• W2077283409 cites W2013321991 @default.
• W2077283409 cites W2015220614 @default.
• W2077283409 cites W2028764424 @default.
• W2077283409 cites W2037449579 @default.
• W2077283409 cites W2041082769 @default.
• W2077283409 cites W2051192069 @default.
• W2077283409 cites W2060340942 @default.
• W2077283409 cites W2062105642 @default.
• W2077283409 cites W2063127584 @default.
• W2077283409 cites W2066114348 @default.
• W2077283409 cites W2069714615 @default.
• W2077283409 cites W2070431968 @default.
• W2077283409 cites W2073509427 @default.
• W2077283409 cites W2075777344 @default.
• W2077283409 cites W2079588650 @default.
• W2077283409 cites W2080769543 @default.
• W2077283409 cites W2089735151 @default.
• W2077283409 cites W2090204137 @default.
• W2077283409 cites W2091015249 @default.
• W2077283409 cites W2097823048 @default.
• W2077283409 cites W2105752797 @default.
• W2077283409 cites W2235962156 @default.
• W2077283409 doi "https://doi.org/10.1016/0027-5107(77)90127-0" @default.
• W2077283409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/325398" @default.
• W2077283409 hasPublicationYear "1977" @default.
• W2077283409 type Work @default.
• W2077283409 sameAs 2077283409 @default.
• W2077283409 citedByCount "17" @default.
• W2077283409 countsByYear W20772834092012 @default.
• W2077283409 countsByYear W20772834092018 @default.
• W2077283409 crossrefType "journal-article" @default.
• W2077283409 hasAuthorship W2077283409A5037093070 @default.
• W2077283409 hasAuthorship W2077283409A5065292122 @default.
• W2077283409 hasConcept C102306862 @default.
• W2077283409 hasConcept C104317684 @default.
• W2077283409 hasConcept C134935766 @default.
• W2077283409 hasConcept C153911025 @default.
• W2077283409 hasConcept C161790260 @default.
• W2077283409 hasConcept C16318435 @default.
• W2077283409 hasConcept C164361826 @default.
• W2077283409 hasConcept C185592680 @default.
• W2077283409 hasConcept C2776639595 @default.
• W2077283409 hasConcept C2776900477 @default.
• W2077283409 hasConcept C2779115727 @default.
• W2077283409 hasConcept C2780625556 @default.
• W2077283409 hasConcept C501734568 @default.
• W2077283409 hasConcept C54355233 @default.
• W2077283409 hasConcept C547475151 @default.
• W2077283409 hasConcept C552990157 @default.
• W2077283409 hasConcept C55493867 @default.
• W2077283409 hasConcept C86803240 @default.
• W2077283409 hasConceptScore W2077283409C102306862 @default.
• W2077283409 hasConceptScore W2077283409C104317684 @default.
• W2077283409 hasConceptScore W2077283409C134935766 @default.
• W2077283409 hasConceptScore W2077283409C153911025 @default.
• W2077283409 hasConceptScore W2077283409C161790260 @default.
• W2077283409 hasConceptScore W2077283409C16318435 @default.
• W2077283409 hasConceptScore W2077283409C164361826 @default.
• W2077283409 hasConceptScore W2077283409C185592680 @default.
• W2077283409 hasConceptScore W2077283409C2776639595 @default.
• W2077283409 hasConceptScore W2077283409C2776900477 @default.
• W2077283409 hasConceptScore W2077283409C2779115727 @default.
• W2077283409 hasConceptScore W2077283409C2780625556 @default.
• W2077283409 hasConceptScore W2077283409C501734568 @default.
• W2077283409 hasConceptScore W2077283409C54355233 @default.
• W2077283409 hasConceptScore W2077283409C547475151 @default.
• W2077283409 hasConceptScore W2077283409C552990157 @default.
• W2077283409 hasConceptScore W2077283409C55493867 @default.
• W2077283409 hasConceptScore W2077283409C86803240 @default.
• W2077283409 hasIssue "1" @default.
• W2077283409 hasLocation W20772834091 @default.
• W2077283409 hasLocation W20772834092 @default.
• W2077283409 hasOpenAccess W2077283409 @default.
• W2077283409 hasPrimaryLocation W20772834091 @default.

• next