FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077288582> ?p ?o ?g. }

• W2077288582 endingPage "7133" @default.
• W2077288582 startingPage "7129" @default.
• W2077288582 abstract "Affinity selection of a 15-mer random peptide library displayed on bacteriophage M13 has been used to identify potent ligands for the human urokinase receptor, a key mediator of tumor cell invasion. A family of receptor binding bacteriophage ligands was obtained by sequentially and alternately selecting the peptide library on COS-7 monkey kidney cells and baculovirus-infected Sf9 insect cells overexpressing the human urokinase receptor. Nineteen peptides encoded by the random DNA regions of the selected bacteriophage were synthesized and tested in a urokinase receptor binding assay, where they competed with the labeled N-terminal fragment of urokinase with IC50 values ranging from 10 nM to 10 microM. All of the isolated peptides were linear and showed two relatively short conserved subsequences: LWXXAr (Ar = Y, W, F, or H) and XFXXYLW, neither of which is found in urokinase or its receptor. Competition experiments demonstrated that the most potent peptide, clone 20, prevented binding of bacteriophage displaying the urokinase receptor binding sequence (urokinase residues 13-32). In addition, this peptide blocked other apparently unrelated receptor binding bacteriophage, suggesting overlapping receptor interaction sites for all of these sequences. These results provide a demonstration of bacteriophage display identifying peptide ligands for a receptor expressed on cells and yield leads for the development of urokinase receptor antagonists." @default.
• W2077288582 created "2016-06-24" @default.
• W2077288582 creator A5033574497 @default.
• W2077288582 creator A5038023087 @default.
• W2077288582 creator A5040381447 @default.
• W2077288582 creator A5042612584 @default.
• W2077288582 date "1994-07-19" @default.
• W2077288582 modified "2023-10-18" @default.
• W2077288582 title "High-affinity urokinase receptor antagonists identified with bacteriophage peptide display." @default.
• W2077288582 cites W1495239533 @default.
• W2077288582 cites W1506729263 @default.
• W2077288582 cites W1548496378 @default.
• W2077288582 cites W1556047524 @default.
• W2077288582 cites W1563512755 @default.
• W2077288582 cites W1598321878 @default.
• W2077288582 cites W1599282089 @default.
• W2077288582 cites W1604744894 @default.
• W2077288582 cites W1611413521 @default.
• W2077288582 cites W1624291957 @default.
• W2077288582 cites W1853643611 @default.
• W2077288582 cites W1946447176 @default.
• W2077288582 cites W1960937091 @default.
• W2077288582 cites W1973322293 @default.
• W2077288582 cites W1976901977 @default.
• W2077288582 cites W1996427305 @default.
• W2077288582 cites W1996796847 @default.
• W2077288582 cites W1997375815 @default.
• W2077288582 cites W1998261194 @default.
• W2077288582 cites W2010649076 @default.
• W2077288582 cites W2011261569 @default.
• W2077288582 cites W2019144916 @default.
• W2077288582 cites W2025864476 @default.
• W2077288582 cites W2038911909 @default.
• W2077288582 cites W2039175545 @default.
• W2077288582 cites W2043813981 @default.
• W2077288582 cites W205532431 @default.
• W2077288582 cites W2057790488 @default.
• W2077288582 cites W2060542507 @default.
• W2077288582 cites W2064988813 @default.
• W2077288582 cites W2068922572 @default.
• W2077288582 cites W2084429764 @default.
• W2077288582 cites W2084649550 @default.
• W2077288582 cites W2089079207 @default.
• W2077288582 cites W2089445064 @default.
• W2077288582 cites W2115947409 @default.
• W2077288582 cites W2134311390 @default.
• W2077288582 cites W2413372306 @default.
• W2077288582 cites W2749679400 @default.
• W2077288582 cites W326908852 @default.
• W2077288582 cites W95550904 @default.
• W2077288582 doi "https://doi.org/10.1073/pnas.91.15.7129" @default.
• W2077288582 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/44352" @default.
• W2077288582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8041758" @default.
• W2077288582 hasPublicationYear "1994" @default.
• W2077288582 type Work @default.
• W2077288582 sameAs 2077288582 @default.
• W2077288582 citedByCount "183" @default.
• W2077288582 countsByYear W20772885822012 @default.
• W2077288582 countsByYear W20772885822013 @default.
• W2077288582 countsByYear W20772885822014 @default.
• W2077288582 countsByYear W20772885822015 @default.
• W2077288582 countsByYear W20772885822016 @default.
• W2077288582 countsByYear W20772885822017 @default.
• W2077288582 countsByYear W20772885822018 @default.
• W2077288582 countsByYear W20772885822019 @default.
• W2077288582 countsByYear W20772885822020 @default.
• W2077288582 countsByYear W20772885822021 @default.
• W2077288582 countsByYear W20772885822022 @default.
• W2077288582 crossrefType "journal-article" @default.
• W2077288582 hasAuthorship W2077288582A5033574497 @default.
• W2077288582 hasAuthorship W2077288582A5038023087 @default.
• W2077288582 hasAuthorship W2077288582A5040381447 @default.
• W2077288582 hasAuthorship W2077288582A5042612584 @default.
• W2077288582 hasBestOaLocation W20772885822 @default.
• W2077288582 hasConcept C104317684 @default.
• W2077288582 hasConcept C153911025 @default.
• W2077288582 hasConcept C167625842 @default.
• W2077288582 hasConcept C170493617 @default.
• W2077288582 hasConcept C186268636 @default.
• W2077288582 hasConcept C2776441376 @default.
• W2077288582 hasConcept C2776471321 @default.
• W2077288582 hasConcept C2776892390 @default.
• W2077288582 hasConcept C2779281246 @default.
• W2077288582 hasConcept C54355233 @default.
• W2077288582 hasConcept C547475151 @default.
• W2077288582 hasConcept C55493867 @default.
• W2077288582 hasConcept C56219504 @default.
• W2077288582 hasConcept C86803240 @default.
• W2077288582 hasConceptScore W2077288582C104317684 @default.
• W2077288582 hasConceptScore W2077288582C153911025 @default.
• W2077288582 hasConceptScore W2077288582C167625842 @default.
• W2077288582 hasConceptScore W2077288582C170493617 @default.
• W2077288582 hasConceptScore W2077288582C186268636 @default.
• W2077288582 hasConceptScore W2077288582C2776441376 @default.
• W2077288582 hasConceptScore W2077288582C2776471321 @default.
• W2077288582 hasConceptScore W2077288582C2776892390 @default.
• W2077288582 hasConceptScore W2077288582C2779281246 @default.
• W2077288582 hasConceptScore W2077288582C54355233 @default.

• next