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• W2077290464 abstract "We have previously demonstrated that in some non–insulin-sensitive tissues (capillaries of eel swimbladder Rete mirabile, and rabbit eye choroidocapillary lamina, optic nerve, retina, and lens) glucose phosphorylation increases with the increase in the concentration of glucose, a characteristic relevant to the hyperglycemia of diabetes. In the present research we demonstrate an effect of the aldose reductase inhibitor, Tolrestat, on the glucose-phosphorylating activity of rabbit lens and optic nerve, by assaying the enzyme activity of tissue homogenates (in the presence of 10 mmol/L glucose) without or with 10 min preincubation with increasing concentrations of Tolrestat (2, 4, and 8 μmol/L). In the lens, a 18% inhibition (p < 0.01) was observed in the presence of 8 μmol/L Tolrestat. In the optic nerve, a 12% (p < 0.05) and a 21% (p < 0.01) reduction was recorded at 4 and 8 μmol/L Tolrestat, respectively. Significant inverse correlations existed between the concentration of Tolrestat and the phosphorylation rate of glucose of rabbit lens and optic nerve. The dose-dependent inhibition of glucose phosphorylation observed by us suggests that the inhibitory action of Tolrestat on glucose metabolism extends beyond the well-known effects of this compound on the polyol pathway, and might contribute to the refraining action of Tolrestat on the development and progression of late diabetic complications in non–insulin- sensitive tissues." @default.
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• W2077290464 date "1999-03-01" @default.
• W2077290464 modified "2023-09-27" @default.
• W2077290464 title "In Vitro Inhibition of Glucose Phosphorylation by an Aldose-Reductase Inhibitor (Tolrestat) in Some Non–Insulin-Sensitive Rabbit Tissues" @default.
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• W2077290464 doi "https://doi.org/10.1016/s1056-8727(98)00027-0" @default.
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