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• W2077293044 endingPage "e34840" @default.
• W2077293044 startingPage "e34840" @default.
• W2077293044 abstract "Rheumatoid arthritis (RA) is a chronic inflammatory disorder with a polygenic mode of inheritance. This study examined the hypothesis that runs of homozygosity (ROHs) play a recessive-acting role in the underlying RA genetic mechanism and identified RA-associated ROHs. Ours is the first genome-wide homozygosity association study for RA and characterized the ROH patterns associated with RA in the genomes of 2,000 RA patients and 3,000 normal controls of the Wellcome Trust Case Control Consortium. Genome scans consistently pinpointed two regions within the human major histocompatibility complex region containing RA-associated ROHs. The first region is from 32,451,664 bp to 32,846,093 bp (−log10(p)>22.6591). RA-susceptibility genes, such as HLA-DRB1, are contained in this region. The second region ranges from 32,933,485 bp to 33,585,118 bp (−log10(p)>8.3644) and contains other HLA-DPA1 and HLA-DPB1 genes. These two regions are physically close but are located in different blocks of linkage disequilibrium, and ∼40% of the RA patients' genomes carry these ROHs in the two regions. By analyzing homozygote intensities, an ROH that is anchored by the single nucleotide polymorphism rs2027852 and flanked by HLA-DRB6 and HLA-DRB1 was found associated with increased risk for RA. The presence of this risky ROH provides a 62% accuracy to predict RA disease status. An independent genomic dataset from 868 RA patients and 1,194 control subjects of the North American Rheumatoid Arthritis Consortium successfully validated the results obtained using the Wellcome Trust Case Control Consortium data. In conclusion, this genome-wide homozygosity association study provides an alternative to allelic association mapping for the identification of recessive variants responsible for RA. The identified RA-associated ROHs uncover recessive components and missing heritability associated with RA and other autoimmune diseases." @default.
• W2077293044 created "2016-06-24" @default.
• W2077293044 creator A5031636838 @default.
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• W2077293044 creator A5084398188 @default.
• W2077293044 date "2012-04-20" @default.
• W2077293044 modified "2023-10-15" @default.
• W2077293044 title "A Genome-Wide Homozygosity Association Study Identifies Runs of Homozygosity Associated with Rheumatoid Arthritis in the Human Major Histocompatibility Complex" @default.
• W2077293044 cites W1492379322 @default.
• W2077293044 cites W1545403291 @default.
• W2077293044 cites W1571100576 @default.
• W2077293044 cites W1635285836 @default.
• W2077293044 cites W1965555277 @default.
• W2077293044 cites W1966057584 @default.
• W2077293044 cites W1966774918 @default.
• W2077293044 cites W1967166230 @default.
• W2077293044 cites W1976875150 @default.
• W2077293044 cites W1983142005 @default.
• W2077293044 cites W1987055888 @default.
• W2077293044 cites W1988276998 @default.
• W2077293044 cites W1989976890 @default.
• W2077293044 cites W1990226212 @default.
• W2077293044 cites W1994402720 @default.
• W2077293044 cites W1996144785 @default.
• W2077293044 cites W2001620383 @default.
• W2077293044 cites W2001931464 @default.
• W2077293044 cites W2002782080 @default.
• W2077293044 cites W2005405421 @default.
• W2077293044 cites W2005817811 @default.
• W2077293044 cites W2008239800 @default.
• W2077293044 cites W2015391036 @default.
• W2077293044 cites W2015865604 @default.
• W2077293044 cites W2017649101 @default.
• W2077293044 cites W2023073368 @default.
• W2077293044 cites W2025408360 @default.
• W2077293044 cites W2026416497 @default.
• W2077293044 cites W2026615227 @default.
• W2077293044 cites W2034700049 @default.
• W2077293044 cites W2035036601 @default.
• W2077293044 cites W2035281059 @default.
• W2077293044 cites W2036314359 @default.
• W2077293044 cites W2039356250 @default.
• W2077293044 cites W2039787241 @default.
• W2077293044 cites W2042728940 @default.
• W2077293044 cites W2052235739 @default.
• W2077293044 cites W2053382138 @default.
• W2077293044 cites W2055262785 @default.
• W2077293044 cites W2055543630 @default.
• W2077293044 cites W2055552847 @default.
• W2077293044 cites W2056392803 @default.
• W2077293044 cites W2061819326 @default.
• W2077293044 cites W2065805602 @default.
• W2077293044 cites W2066669827 @default.
• W2077293044 cites W2074438676 @default.
• W2077293044 cites W2080817427 @default.
• W2077293044 cites W2082458448 @default.
• W2077293044 cites W2085328927 @default.
• W2077293044 cites W2088706525 @default.
• W2077293044 cites W2089469712 @default.
• W2077293044 cites W2093503233 @default.
• W2077293044 cites W2097757648 @default.
• W2077293044 cites W2103089222 @default.
• W2077293044 cites W2107576399 @default.
• W2077293044 cites W2115783720 @default.
• W2077293044 cites W2122280942 @default.
• W2077293044 cites W2127316801 @default.
• W2077293044 cites W2127450586 @default.
• W2077293044 cites W2129276253 @default.
• W2077293044 cites W2134783591 @default.
• W2077293044 cites W2134890298 @default.
• W2077293044 cites W2137073429 @default.
• W2077293044 cites W2140247198 @default.
• W2077293044 cites W2146293362 @default.
• W2077293044 cites W2146948473 @default.
• W2077293044 cites W2149681218 @default.
• W2077293044 cites W2151286925 @default.
• W2077293044 cites W2153362877 @default.
• W2077293044 cites W2156866331 @default.
• W2077293044 cites W2157752701 @default.
• W2077293044 cites W2161633633 @default.
• W2077293044 cites W2162276444 @default.
• W2077293044 cites W2168781986 @default.
• W2077293044 cites W2169421412 @default.
• W2077293044 cites W2170238366 @default.
• W2077293044 cites W2172252592 @default.
• W2077293044 cites W2426335134 @default.
• W2077293044 cites W4252684946 @default.
• W2077293044 doi "https://doi.org/10.1371/journal.pone.0034840" @default.
• W2077293044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3335047" @default.
• W2077293044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22536334" @default.
• W2077293044 hasPublicationYear "2012" @default.
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