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- W2077293863 abstract "A novel and practical synthetic route for the preparation of candesartan cilexetil from methyl 2-amino-3-nitrobenzoate is described. The key steps are the reaction of methyl 2-bromo-3-(diethoxymethyleneamino)benzoate with (2′-(1-trityl-1H-tetrazol-5-yl) biphenyl-4-yl) methanamine and the final formation of 2-ethoxy benzimidazole ring via intramolecular N-arylation. The final ring closure process could be utilized to prepare other 2-substituted benzimidazoles. The method is simple for operation and suitable for industrial production." @default.
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- W2077293863 date "2010-07-01" @default.
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- W2077293863 title "A novel and practical synthesis of substituted 2-ethoxy benzimidazole: candesartan cilexetil" @default.
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