FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077303414> ?p ?o ?g. }

• W2077303414 endingPage "80" @default.
• W2077303414 startingPage "59" @default.
• W2077303414 abstract "A theoretical model has been developed to evaluate possible designs for an insulin delivery system which is responsive to glucose. The system is based upon a glucose sensitive hydrogel containing immobilized glucose oxidase and catalase. The requirement of molecular oxygen for the enzymic reactions ordinarily limits the response of the system to levels of glucose (less than 50 mg%) below the patho-physiological range (50–1000 mg%) The theoretical model dcveloned desrnbes the transient as well as steady state diffusion and reaction of glucose, oxygen and gluconic acid within the macroporous hydrogel for various designs chosen to alleviate the oxygen limitation. The designs are evaluated in terms of the average pH change within the gel in response to increasing concentrations of glucose. The model predicts the oxygen limitation that has been seen experimentally for a thin glucose sensitive membrane (GSM). The modeling studies have also revealed four device configurations that overcome this limitation. Each design uses silicone rubber to create additional pathways for oxygen delivery to the gel interior. A thin GSM loaded with insulin and placed over a silicone rubber drum, sealed to form a gaseous reservoir, was found to be sensitive to glucose concentrations in the 0–500 mg% range. A second design using a silicone rubber tube filled with GSM (also preloaded with insulin), exhibited glucose sensitivity in the 0–400 mg% range. A combined design, with a central gaseous reservoir bounded by plugs of GSM in a silicone rubber tube, retained a linear response even in the 300–500 rag% range. Finally a fourth design, with an insulin loaded GSM sandwiched between two circular films of silicone rubber sheeting, was sensitive in the 0–200 mg% range. Further considerations of response time, insulin loading and delivery capacity are also discussed." @default.
• W2077303414 created "2016-06-24" @default.
• W2077303414 creator A5004866725 @default.
• W2077303414 creator A5063506732 @default.
• W2077303414 date "1992-01-01" @default.
• W2077303414 modified "2023-10-06" @default.
• W2077303414 title "Design of insulin delivery devices based on glucose sensitive membranes" @default.
• W2077303414 cites W1536204744 @default.
• W2077303414 cites W1561551858 @default.
• W2077303414 cites W1839812342 @default.
• W2077303414 cites W1964532053 @default.
• W2077303414 cites W1989947315 @default.
• W2077303414 cites W2004514138 @default.
• W2077303414 cites W2004976115 @default.
• W2077303414 cites W2005504986 @default.
• W2077303414 cites W2007575820 @default.
• W2077303414 cites W2011358589 @default.
• W2077303414 cites W2013512466 @default.
• W2077303414 cites W2019732275 @default.
• W2077303414 cites W2023343321 @default.
• W2077303414 cites W2034304758 @default.
• W2077303414 cites W2047929780 @default.
• W2077303414 cites W2050377760 @default.
• W2077303414 cites W2066438671 @default.
• W2077303414 cites W2071717545 @default.
• W2077303414 cites W2085466845 @default.
• W2077303414 cites W2091288913 @default.
• W2077303414 cites W2115818403 @default.
• W2077303414 cites W2144934384 @default.
• W2077303414 cites W2156224745 @default.
• W2077303414 cites W2170143296 @default.
• W2077303414 cites W4232625102 @default.
• W2077303414 cites W4235108561 @default.
• W2077303414 doi "https://doi.org/10.1016/0168-3659(92)90212-a" @default.
• W2077303414 hasPublicationYear "1992" @default.
• W2077303414 type Work @default.
• W2077303414 sameAs 2077303414 @default.
• W2077303414 citedByCount "89" @default.
• W2077303414 countsByYear W20773034142012 @default.
• W2077303414 countsByYear W20773034142013 @default.
• W2077303414 countsByYear W20773034142014 @default.
• W2077303414 countsByYear W20773034142015 @default.
• W2077303414 countsByYear W20773034142016 @default.
• W2077303414 countsByYear W20773034142017 @default.
• W2077303414 countsByYear W20773034142018 @default.
• W2077303414 countsByYear W20773034142019 @default.
• W2077303414 countsByYear W20773034142020 @default.
• W2077303414 countsByYear W20773034142021 @default.
• W2077303414 countsByYear W20773034142022 @default.
• W2077303414 crossrefType "journal-article" @default.
• W2077303414 hasAuthorship W2077303414A5004866725 @default.
• W2077303414 hasAuthorship W2077303414A5063506732 @default.
• W2077303414 hasConcept C127413603 @default.
• W2077303414 hasConcept C134018914 @default.
• W2077303414 hasConcept C160756335 @default.
• W2077303414 hasConcept C178790620 @default.
• W2077303414 hasConcept C185592680 @default.
• W2077303414 hasConcept C192562407 @default.
• W2077303414 hasConcept C2776290925 @default.
• W2077303414 hasConcept C2777197210 @default.
• W2077303414 hasConcept C2779306644 @default.
• W2077303414 hasConcept C2779769944 @default.
• W2077303414 hasConcept C2780388412 @default.
• W2077303414 hasConcept C41625074 @default.
• W2077303414 hasConcept C42360764 @default.
• W2077303414 hasConcept C43617362 @default.
• W2077303414 hasConcept C540031477 @default.
• W2077303414 hasConcept C55493867 @default.
• W2077303414 hasConcept C71924100 @default.
• W2077303414 hasConceptScore W2077303414C127413603 @default.
• W2077303414 hasConceptScore W2077303414C134018914 @default.
• W2077303414 hasConceptScore W2077303414C160756335 @default.
• W2077303414 hasConceptScore W2077303414C178790620 @default.
• W2077303414 hasConceptScore W2077303414C185592680 @default.
• W2077303414 hasConceptScore W2077303414C192562407 @default.
• W2077303414 hasConceptScore W2077303414C2776290925 @default.
• W2077303414 hasConceptScore W2077303414C2777197210 @default.
• W2077303414 hasConceptScore W2077303414C2779306644 @default.
• W2077303414 hasConceptScore W2077303414C2779769944 @default.
• W2077303414 hasConceptScore W2077303414C2780388412 @default.
• W2077303414 hasConceptScore W2077303414C41625074 @default.
• W2077303414 hasConceptScore W2077303414C42360764 @default.
• W2077303414 hasConceptScore W2077303414C43617362 @default.
• W2077303414 hasConceptScore W2077303414C540031477 @default.
• W2077303414 hasConceptScore W2077303414C55493867 @default.
• W2077303414 hasConceptScore W2077303414C71924100 @default.
• W2077303414 hasIssue "1" @default.
• W2077303414 hasLocation W20773034141 @default.
• W2077303414 hasOpenAccess W2077303414 @default.
• W2077303414 hasPrimaryLocation W20773034141 @default.
• W2077303414 hasRelatedWork W2012449665 @default.
• W2077303414 hasRelatedWork W2026776474 @default.
• W2077303414 hasRelatedWork W2056661539 @default.
• W2077303414 hasRelatedWork W2060972204 @default.
• W2077303414 hasRelatedWork W2135975437 @default.
• W2077303414 hasRelatedWork W2259038753 @default.
• W2077303414 hasRelatedWork W2591586996 @default.
• W2077303414 hasRelatedWork W27028060 @default.

• next