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• W2077304073 abstract "ABSTRACT Prion diseases are fatal neurodegenerative disorders characterized by accumulation of PrP Sc , vacuolation of neurons and neuropil, astrocytosis, and microglial activation. Upregulation of gene expressions of innate immunity-related factors, including complement factors and CD14, is observed in the brains of mice infected with prions even in the early stage of infections. When CD14 knockout (CD14 −/− ) mice were infected intracerebrally with the Chandler and Obihiro prion strains, the mice survived longer than wild-type (WT) mice, suggesting that CD14 influences the progression of the prion disease. Immunofluorescence staining that can distinguish normal prion protein from the disease-specific form of prion protein (PrP Sc ) revealed that deposition of PrP Sc was delayed in CD14 −/− mice compared with WT mice by the middle stage of the infection. Immunohistochemical staining with Iba1, a marker for activated microglia, showed an increased microglial activation in prion-infected CD14 −/− mice compared to WT mice. Interestingly, accompanied by the increased microglial activation, anti-inflammatory cytokines interleukin-10 (IL-10) and transforming growth factor β (TGF-β) appeared to be expressed earlier in prion-infected CD14 −/− mice. In contrast, IL-1β expression appeared to be reduced in the CD14 −/− mice in the early stage of infection. Double immunofluorescence staining demonstrated that CD11b- and Iba1-positive microglia mainly produced the anti-inflammatory cytokines, suggesting anti-inflammatory status of microglia in the CD14 −/− mice in the early stage of infection. These results imply that CD14 plays a role in the disease progression by suppressing anti-inflammatory responses in the brain in the early stage of infection." @default.
• W2077304073 created "2016-06-24" @default.
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• W2077304073 date "2013-12-15" @default.
• W2077304073 modified "2023-10-17" @default.
• W2077304073 title "Absence of CD14 Delays Progression of Prion Diseases Accompanied by Increased Microglial Activation" @default.
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• W2077304073 doi "https://doi.org/10.1128/jvi.02072-13" @default.
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