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- W2077305587 abstract "The effect of morphine sulfate (MS) on adenylate cyclase (AC) and phosphodiesterase (PDE) activities in the rat striatum was investigated. MS produced a dose-dependent increase in basal AC activity and did not alter sodium fluoride-induced stimulation both invivo (7.5–30 mg/kg, 1 hr pretreatment, i.p.) and invitro (1–100μM). invitro, when submaximal effective concentrations of dopamine and MS were combined, there was an additive effect. However, administration of MS invivo did not alter dopamine-induced stimulation of AC activity. MS, invitro and invivo inhibited PDE activity in a dose-dependent manner only with the high substrate concentration (3.3 × 10−3M cyclic AMP). Preliminary results from this study indicate that morphine affects the cyclic AMP system." @default.
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- W2077305587 date "1975-03-01" @default.
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- W2077305587 title "Effect of morphine sulfate on adenylate cyclase and phosphodiesterase activities in rat corpus striatum" @default.
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- W2077305587 doi "https://doi.org/10.1016/0024-3205(75)90352-5" @default.
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