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- W2077329291 abstract "The safety of injecting discordant xenogeneic fetal endocrine pancreatic tissue into the portal vein was studied in a pig-to-dog system. It was found that minced fetal porcine pancreas and fetal porcine isletlike cell clusters prepared by collagenase digestion and culture could be injected with only minor or no hepatic hemo-dynamic disturbances. Coagulation studies revealed a small increase in plasma fibrinopeptide A, but this increase could be prevented by heparinization of the recipient. There was no consumption of fibrinogen or platelets. In contrast, injection of minced adult porcine pancreas caused pronounced hepatic hemodynamic changes and marked coagulation abnormalities, indicating consumption coagulopathy. The present finding that fetal porcine pancreas can be injected intraportally without deleterious effects in dogs provides a foundation for the eventual clinical use of such material as treatment for insulin-dependent diabetes mellitus." @default.
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- W2077329291 date "1992-01-01" @default.
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- W2077329291 title "INJECTION OF XENOGENEIC ENDOCRINE PANCREATIC TISSUE INTO THE PORTAL VEIN—EFFECTS ON COAGULATION, LIVER FUNCTION, AND HEPATIC HEMODYNAMICS" @default.
- W2077329291 doi "https://doi.org/10.1097/00007890-199201000-00028" @default.
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