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• W2077334858 abstract "Recovery from optic neuritis has been shown to be associated with an abnormal functional MRI (fMRI) response following exposure of the eye to an epoch based (ON-OFF design) flickering photic stimulus. Visual cortex activation is reduced during photic stimulation, whilst extra-occipital areas are extensively activated with a peak blood oxygen level dependent response during the OFF phase of the stimulus paradigm. We performed a further fMRI experiment to determine whether the abnormal extra-occipital response is a phase-specific phenomenon or whether it results from a delayed haemodynamic response. A cohort of patients that recovered from optic neuritis was studied, this time using a longer photic stimulation epoch (40 s). The extra-occipital response again peaked during the baseline condition, indicating that the phenomenon is phase dependent. Our results also reinforce the important findings of extra-occipital activation following optic neuritis which may represent an adaptive reorganization of the cerebral response." @default.
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• W2077334858 date "2002-09-01" @default.
• W2077334858 modified "2023-10-18" @default.
• W2077334858 title "Functional magnetic resonance imaging of the cortical response to photic stimulation in humans following optic neuritis recovery" @default.
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• W2077334858 doi "https://doi.org/10.1016/s0304-3940(02)00700-0" @default.
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