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- W2077335373 abstract "To study the effect of vitamin E dosage form and route of administration on tissue levels of vitamin E, newborn rabbit pups were given 100 mg/kg/day of α-tocopherol (T) or α-tocopherol acetate (TA) sc, po, and iv. Various tissues were obtained on days 1, 3, and 6 of life and analyzed for T and TC using HPLC. (All values represent mean ± SD, μg/g tissue, n=3-5). T levels in lung 1 day after T dosing were 36 ± 9 (sc), 13 ± 4 (po), and 92 ± 16 (iv); liver levels were 493 ± 110 (sc), 138 ± 73 (po), and 1362 ± 570 (iv). T tissue levels 1 day after sc TA administration were no different than controls (all ≤ 8 μg/g). T tissue levels 1 day after po and iv administration of TA were 18 ± 8 (po) and 79 ± 47 (iv) for lung and 253 ± 36 (po) and 10 ± 5 (iv) in liver. No TA was seen in tissues after po TA administration. In contrast, iv administration of TA resulted in tissue levels of TA at 1 day of 3957 ± 2589 in lung and 48 ± 30 in liver. T and TA tissue levels after 3 and 6 days of daily dosing with T or TA were similar to the 1-day data in distribution although increased in amount. From the results, we conclude that T given parenterally or orally results in marked increases in T tissue levels; whereas parenteral TA administration does not increase T tissue levels. Extensive hydrolysis of TA to T occurs with po administration of TA, but only minimal hydrolysis occurs with parenteral routes of administration. When given parenterally, TA may be ineffective as an antioxidant. (Supported in part by NIH GM12675.)" @default.
- W2077335373 created "2016-06-24" @default.
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- W2077335373 date "1984-04-01" @default.
- W2077335373 modified "2023-10-18" @default.
- W2077335373 title "DISPOSITION OF PHARMACOLOGICAL DOSES OF VITAMIN E IN NEWBORN RABBITS" @default.
- W2077335373 doi "https://doi.org/10.1203/00006450-198404001-00365" @default.
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