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- W2077339937 endingPage "145" @default.
- W2077339937 startingPage "135" @default.
- W2077339937 abstract "In many individuals with major neuropsychiatric disorders including depression, bipolar disorder and schizophrenia, their disease characteristics are consistent with a neuroprogressive illness. This includes progressive structural brain changes, cognitive and functional decline, poorer treatment response and an increasing vulnerability to relapse with chronicity. The underlying molecular mechanisms of neuroprogression are thought to include neurotrophins and regulation of neurogenesis and apoptosis, neurotransmitters, inflammatory, oxidative and nitrosative stress, mitochondrial dysfunction, cortisol and the hypothalamic-pituitary-adrenal axis, and epigenetic influences. Knowledge of the involvement of each of these pathways implies that specific agents that act on some or multiple of these pathways may thus block this cascade and have neuroprotective properties. This paper reviews the potential of the most promising of these agents, including lithium and other known psychotropics, aspirin, minocycline, statins, N-acetylcysteine, leptin and melatonin. These agents are putative neuroprotective agents for schizophrenia and mood disorders." @default.
- W2077339937 created "2016-06-24" @default.
- W2077339937 creator A5032880777 @default.
- W2077339937 creator A5038776015 @default.
- W2077339937 creator A5042626878 @default.
- W2077339937 creator A5042812626 @default.
- W2077339937 creator A5076811625 @default.
- W2077339937 creator A5078882374 @default.
- W2077339937 date "2013-04-01" @default.
- W2077339937 modified "2023-10-11" @default.
- W2077339937 title "Putative neuroprotective agents in neuropsychiatric disorders" @default.
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