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- W2077341167 abstract "Abstract The usefulness of measuring tablet surface areas by a permeametry technique for the characterization of particle fragmentation during compaction was evaluated. Eight materials (sieve fraction 212–250 μm) with varying and documented consolidation behavior were compacted at a series of pressures in the range 20–200 MPa. The permeability of the tablets was measured and the specific surface area of the tablets was calculated. For all materials the tablet surface area increased with increased compaction pressure within the pressure range studied. However the slope of the curves differed between the materials and they could be rank ordered in agreement with earlier experiences of their fragmentation propensity. The permeametry procedure therefore seems acceptable for estimating particle fragmentation during compaction." @default.
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- W2077341167 title "Studies on direct compression of tablets. XL Characterization of particle fragmentation during compaction by permeametry measurements of tablets☆" @default.
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